Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/10742
Lifestyle and Progression to Type 2 Diabetes in a Cohort of Workers with Prediabetes
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DOI: 10.3390/nu12051538
eISSN: 2072-6643
WOS ID: 000542272700204
Scopus EID: 2-s2.0-85085621186
PMID: 32466178
Embase PUI: L2004449153
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2020-05Document type
research articleCitation
Bennasar-Veny M, Fresneda S, Lopez-Gonzalez A, Busquets-Cortes C, Aguilo A, Yañez AM. Lifestyle and Progression to Type 2 Diabetes in a Cohort of Workers with Prediabetes. Nutrients. 2020 May;12(5):1538.Abstract
Background: People with prediabetes have an increased risk of developing type 2 diabetes (T2D). Few studies have evaluated the influence of lifestyle factors on the risk of progression to diabetes and reversion to normoglycemia. The aim of this study was to determine the incidence of T2D in a large cohort of workers with prediabetes, and to evaluate the influence of sociodemographic, clinical, metabolic, and lifestyle factors that affect the persistence of prediabetes and the progression to T2D. Methods: A cohort study of 27,844 adult workers (aged 20 to 65 years) from Spain who had prediabetes based on an occupational medical examination from 2012 to 2013. Prediabetes was defined as fasting plasma glucose (FPG) between 100 and 125 mg/dL. At the baseline evaluation, sociodemographic, anthropometric, metabolic, and lifestyle data were collected. At the 5-year follow-up, incident T2D was defined as an FPG of at least 126 mg/dL or initiation of an antidiabetic medication. Results: Among 235,995 initially screened workers, the prevalence of T2D was 14.19% (95% confidence interval (CI) 14.05 to 14.33) and the prevalence of prediabetes was 11.85% (95% CI 11.71 to 11.99). Follow-up data were available for 23,293 individuals with prediabetes. Among them, 36.08% (95% CI 35.46 to 36.70) returned to normoglycemia, 40.92% (95% CI 40.29 to 41.55) had persistent prediabetes, and 23.00% (95% CI 22.46 to 23.54) progressed to T2D. The risk for persistence of prediabetes and for progression to T2D increased with age, body mass index (BMI), triglyceride level, and less than 150 min/week of physical activity. An HbA1c level of 6% or greater was the strongest individual predictor of progression to T2D. Conclusions: Physical activity, diet, smoking, and BMI are modifiable factors that are associated with the persistence of prediabetes and the progression to T2D. The workplace is a feasible setting for the early detection of prediabetes and the promotion of lifestyles that can prevent progression to T2D.
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https://dx.doi.org/10.3390/nu12051538Keywords
prediabetesoccupational health
lifestyles
risk factor
diabetes risk
fasting plasma glucose
HbA1c
normoglycemia
reversion
MeSH
Diabetes Mellitus, Type 2Disease Progression
Aged
European Continental Ancestry Group
Blood Glucose
Young Adult
Spain
Adult
Follow-Up Studies
Humans
Life Style
Socioeconomic Factors
Middle Aged
Glycated Hemoglobin A
Hypoglycemic Agents
Prediabetic State
Diet
Male
Female
Risk Factors
Body Mass Index
Cohort Studies
Exercise
Incidence
DeCS
Índice de Masa CorporalEstudios de Cohortes
Ejercicio Físico
Incidencia
Femenino
Dieta
Hemoglobina A Glucada
Grupo de Ascendencia Continental Europea
Masculino
Factores Socioeconómicos
Estudios de Seguimiento
Factores de Riesgo
Hipoglucemiantes
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Diabetes Mellitus Tipo 2
Progresión de la Enfermedad
Adulto
España
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Instituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científicaServicio de Salud de las Islas Baleares - IBSALUT > Comunicación científica