Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/10878
Leukocyte Subtype Counts and Its Association with Vascular Structure and Function in Adults with Intermediate Cardiovascular Risk. MARK Study
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ISSN: 1932-6203
WOS ID: 000353017000007
Scopus EID: 2-s2.0-84929483964
PMID: 25885665
Embase PUI: L604107157
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2015-04-17Document type
research articleCitation
Gomez-Sanchez L, Garcia-Ortiz L, Recio-Rodriguez JI, Patino-Alonso MC, Agudo-Conde C, Rigo Carratala F, et al. Leukocyte Subtype Counts and Its Association with Vascular Structure and Function in Adults with Intermediate Cardiovascular Risk. MARK Study. PLoS One. 2015 Apr 17;10(4):e0119963.Abstract
Objectives We investigated the relationship between leukocyte subtype counts and vascular structure and function based on carotid intima-media thickness, pulse wave velocity, central augmentation index and cardio-ankle vascular index by gender in intermediate cardiovascular risk patients. Methods This study analyzed 500 subjects who were included in the MARK study, aged 35 to 74 years (mean: 60.3 +/- 8.4), 45.6% women. Measurement: Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular Index (CAVI) using the VaSera device and Carotid ultrasound was used to measure carotid Intima Media Thickness (IMT). The Mobil-O-Graph was used to measure the Central Augmentation Index (CAIx). Results Total leukocyte, neutrophil and monocyte counts were positively correlated with IMT (p < 0.01) in men. Monocyte count was positively correlated with CAIx in women (p < 0.01). In a multiple linear regression analysis, the IMT mean maintained a positive association with the neutrophil count (beta = 1.500, p = 0.007) in men. CAIx maintained a positive association with the monocyte count (beta = 2.445, p = 0.022) in women. Conclusion The results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender. In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients. These association were maintained after adjusting for age and other confounders.
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https://dx.doi.org/10.1371/journal.pone.0119963MeSH
Cardiovascular DiseasesAged
Adult
Leukocyte Count
Humans
Pulse Wave Analysis
Neutrophils
Leukocytes
Middle Aged
Blood Pressure
Cross-Sectional Studies
Male
Monocytes
Sex Factors
Carotid Intima-Media Thickness
Female
Vascular Stiffness
Risk Factors
Regression Analysis
Ankle Brachial Index
DeCS
Análisis de la Onda del PulsoFemenino
Monocitos
Masculino
Factores Sexuales
Estudios Transversales
Factores de Riesgo
Índice Tobillo Braquial
Presión Sanguínea
Humanos
Leucocitos
Persona de Mediana Edad
Neutrófilos
Anciano
Grosor Intima-Media Carotídeo
Rigidez Vascular
Enfermedades Cardiovasculares
Adulto
Recuento de Leucocitos
Análisis de Regresión
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Atención Primaria de Mallorca - APMALL > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica