Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/10906
Characterization of Monoclonal Gammopathy of Undetermined Significance by Calorimetric Analysis of Blood Serum Proteome
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ISSN: 1932-6203
WOS ID: 000352083900011
Scopus EID: 2-s2.0-84925745412
PMID: 25794164
Embase PUI: L603270889
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2015-03-20Document type
research articleCitation
Barcelo F, Cerda JJ, Gutierrez A, Jimenez-Marco T, Duran Pastor MA, Novo García A, et al. Characterization of Monoclonal Gammopathy of Undetermined Significance by Calorimetric Analysis of Blood Serum Proteome. PLoS One. 2015 Mar 20;10(3):e0120316.Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant proliferative disorder that may progress to multiple myeloma, a malignant plasma cell neoplasia. We evaluated differential scanning calorimetry (DSC) as an experimental tool for differentiating serum samples of MGUS patients from healthy individuals. DSC thermograms can be used for monitoring changes in the serum proteome associated with MGUS. MGUS patients showed great variability in serum thermogram characteristics, which depended on the IgG, IgA or IgM iso-types and/or the. or. light chains. Thermogram feature parameters distinguished patients with MGUS from healthy people. Serum samples, named as non-MGUS, were also collected from patients with subjacent immunological pathologies who were discarded of having MGUS through serum immunofixation. They were used to verify the sensitivity of DSC for discriminating MGUS from related blood dyscrasias. Only some DSC thermogram feature parameters differentiated, to a lesser extent, between MGUS and non-MGUS individuals. We contemplate DSC as a tool for early diagnosis and monitoring of MGUS.
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https://dx.doi.org/10.1371/journal.pone.0120316MeSH
Aged, 80 and overAged
Blood Proteins
Diagnosis, Differential
Case-Control Studies
Young Adult
Adult
Humans
Monoclonal Gammopathy of Undetermined Significance
Calorimetry, Differential Scanning
Middle Aged
Proteome
Proteomics
Male
Female
DeCS
ProteomaFemenino
Rastreo Diferencial de Calorimetría
Masculino
Humanos
Persona de Mediana Edad
Adulto Joven
Gammopatía Monoclonal de Relevancia Indeterminada
Anciano
Proteómica
Anciano de 80 o más Años
Proteínas Sanguíneas
Adulto
Estudios de Casos y Controles
Diagnóstico Diferencial
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Hospital Universitario Son Espases - HUSE > Comunicación científicaFundación Banco de Sangre y Tejidos de las Islas Baleares - FBSTIB > Comunicación científica
Instituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica