Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/10968
Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation
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ISSN: 1471-2466
WOS ID: 000350588200001
Scopus EID: 2-s2.0-84925234718
PMID: 25595204
Embase PUI: L603143372
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Balcells, Eva; Gimeno-Santos, Elena; de Batlle, Jordi; Antonia Ramon, Maria; Rodriguez, Esther; Benet, Marta; Farrero, Eva; Ferrer, Antoni; Guerra, Stefano; Ferrer, Jaume; Sauleda Roig, Jaume
Publication date
2015-01-17Document type
research articleCitation
Balcells E, Gimeno-Santos E, De Batlle J, Ramon MA, Rodriguez E, Benet M, et al. Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation. BMC Pulm Med. 2015 Jan 17;15:4.Abstract
Background: Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD. Methods: The PAC-COPD cohort included 342 COPD patients hospitalised for the first time for an exacerbation of COPD (2004-2006). Patients were extensively characterised using sociodemographic, clinical and functional variables, and the cohort was followed-up through 2008. We defined undiagnosed COPD by the absence of any self-reported respiratory disease and regular use of any pharmacological respiratory treatment. Results: Undiagnosed COPD was present in 34% of patients. They were younger (mean age 66 vs. 68 years, p = 0.03), reported fewer symptoms (mMRC dyspnoea score, 2.1 vs. 2.6, p < 0.01), and had a better health status (SGRQ total score, 29 vs. 40, p < 0.01), milder airflow limitation (FEV1% ref., 59% vs. 49%, p < 0.01), and fewer comorbidities (two or more, 40% vs. 56%, p < 0.01) when compared with patients with an established COPD diagnosis. Three months after hospital discharge, 16% of the undiagnosed COPD patients had stopped smoking (vs. 5%, p = 0.019). During follow-up, annual hospitalisation rates were lower in undiagnosed COPD patients (0.14 vs. 0.25, p < 0.01); however, this difference disappeared after adjustment for severity. Mortality was similar in both groups. Conclusions: Undiagnosed COPD patients have less severe disease and lower risk of re-hospitalisation when compared with hospitalised patients with known COPD.
Publisher version
https://dx.doi.org/10.1186/1471-2466-15-4Keywords
Pulmonary diseaseChronic obstructive
Hospitalisation
Cohort studies
Epidemiology
Health services
MeSH
AgedDyspnea
Pulmonary Disease, Chronic Obstructive
Follow-Up Studies
Humans
Health Status
Forced Expiratory Volume
Middle Aged
Tobacco Use
Longitudinal Studies
Prognosis
Hospitalization
Male
Self Report
Severity of Illness Index
Female
Smoking Cessation
Comorbidity
Patient Discharge
Surveys and Questionnaires
DeCS
ComorbilidadFemenino
Uso de Tabaco
Hospitalización
Masculino
Estudios de Seguimiento
Volumen Espiratorio Forzado
Enfermedad Pulmonar Obstructiva Crónica
Estudios Longitudinales
Humanos
Persona de Mediana Edad
Estado de Salud
Pronóstico
Anciano
Índice de Severidad de la Enfermedad
Encuestas y Cuestionarios
Disnea
Alta del Paciente
Autoinforme
Cese del Hábito de Fumar
This item appears in following Docusalut collections
Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica