Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/10994
Effects of Polyphenols from Grape Seeds on Renal Lithiasis
Identifiers
DOI: 10.1155/2015/813737
ISSN: 1942-0900
eISSN: 1942-0994
WOS ID: 000353489700001
Scopus EID: 2-s2.0-84927153602
PMID: 25883748
Embase PUI: L603605510
Share
Statistics
Item usage statisticsMetadata
Show Dublin Core item recordPublication date
2015Document type
research articleCitation
Grases F, Prieto RM, Fernandez-Cabot RA, Costa-Bauza A, Tur F, Juan Torres J. Effects of Polyphenols from Grape Seeds on Renal Lithiasis. Oxidative Med Cell Longev. 2015;2015:813737. Epub 2015 Mar 25.Abstract
Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy. Development of calcium oxalate monohydrate papillary calculi is linked to initial subepithelial calcification of renal papilla. Progressive tissue calcification depends on preexisting injury and involves reactive oxygen species. Many plant extracts that protect against oxidative stressmanifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Rats were pretreated with polyphenols and grape seed extracts, followed by posterior induction of hyperoxalosis via treatment with ethylene glycol plus NH4Cl. The concentrations of calcium and other elements in kidney were determined, along with histological examination of kidney and 24 h urine analysis. Significant differences were observed in the renal calcium content between the control plus ethylene glycol-treated group and the epicatechin plus ethylene glycol-treated, red grape seed extract plus ethylene glycol-treated, and white grape seed extract plus ethylene glycol-treated groups, with reductions of about 50%. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation, particularly if calculi are induced by lesions caused by cytotoxic compounds with oxidative capacity.
Publisher version
https://dx.doi.org/10.1155/2015/813737MeSH
Ammonium ChloridePolyphenols
Body Weight
Calcium
Kidney
Lithiasis
Vitis
Kidney Diseases
Catechin
Male
Rats, Wistar
Magnesium
Seeds
Phosphorus
Rats
Animals
Ethylene Glycol
Grape Seed Extract
DeCS
Glicol de EtilenoAnimales
Ratas Wistar
Litiasis
Enfermedades Renales
Catequina
Magnesio
Masculino
Riñón
Fósforo
Semillas
Polifenoles
Ratas
Vitis
Extracto de Semillas de Uva
Cloruro de Amonio
Calcio
Peso Corporal
This item appears in following Docusalut collections
Hospital Comarcal de Inca - HCIN > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica