Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11002
Plant phosphates, phytate and pathological calcifications in chronic kidney disease
StatisticsItem usage statistics
MetadataShow Dublin Core item record
Document typereview article
CitationBuades JM, Sanchis P, Perello Bestard J, Grases F. Plant phosphates, phytate and pathological calcifications in chronic kidney disease. Nefrologia. 2017 Jan;37(1):20-8. Epub 2016 Sep 30.
Phytate, or myo-inositol 1,2,3,4,5,6-hexakis dihydrogen phosphate (InsP6), is a naturally occurring phosphorus compound that is present in many foods, mainly legumes, whole grains and nuts. Patients with chronic kidney disease (CKD) have cardiovascular disease mortality up to 30 times higher than the general population. Vascular calcifications (VCs) directly contribute to overall morbidity and mortality, especially in CKD. In part, this high mortality is due to elevated levels of phosphorus in the blood. Therefore, control of dietary phosphorus is essential. Dietary phosphorus can be classified according to its structure in organic phosphorus (plant and animal) and inorganic (preservatives and additives). Plant phosphorus (legumes and nuts), mainly associated with InsP6, is less absorbable by the human gastrointestinal tract as the bioavailability of phosphorous from plant -derived foods is very low. Recent data indicate that restriction of foods containing plant phosphates may compromise the adequate supply of nutrients that have a beneficial effect in preventing cardiovascular events, such as InsP6 or fibre found in legumes and nuts. Experimental studies in animals and observational studies in humans suggest that InsP6 can prevent lithiasis and VCs and protect from osteoporosis. In conclusion, we need prospective studies to elucidate the potential benefits and risks of phytate (InsP6) through the diet and as an intravenous drug in patients on haemodialysis.
KeywordsChronic kidney disease
This item appears in following Docusalut collectionsInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica
Hospital Universitario Son Llàtzer - HUSLL > Comunicación científica