Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11123
A High Dietary Glycemic Index Increases Total Mortality in a Mediterranean Population at High Cardiovascular Risk
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ISSN: 1932-6203
WOS ID: 000342492700064
Scopus EID: 2-s2.0-84907452298
PMID: 25250626
Embase PUI: L600068008
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Castro-Quezada, Itandehui; Sanchez-Villegas, Almudena; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; Schroeder, Helmut; Alvarez-Perez, Jacqueline; Dolores Ruiz-Lopez, Maria; Artacho, Reyes; Ros, Emilio; Bullo, Monica; Covas, Maria-Isabel; Ruiz-Gutierrez, Valentina; Ruiz-Canela, Miguel; Buil-Cosiales, Pilar; Gomez-Gracia, Enrique; Lapetra, Jose; Pinto, Xavier; Aros, Fernando; Fiol Sala, Miquel

Publication date
2014-09-24Document type
research articleCitation
Castro-Quezada I, Sanchez-Villegas A, Estruch R, Salas-Salvado J, Corella D, Schroeder H, et al. A High Dietary Glycemic Index Increases Total Mortality in a Mediterranean Population at High Cardiovascular Risk. PLoS One. 2014 Sep 24;9(9):e107968.Abstract
Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food frequency questionnaire (FFQ). We assigned GI values of each item by a 5-step methodology, using the International Tables of GI and GL Values. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) and their 95% CI for mortality, according to quartiles of energy-adjusted dietary GI/GL. To assess repeated measures of exposure, we updated GI and GL intakes from the yearly FFQs and used Cox models with time-dependent exposures. Results: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). As compared to participants in the lowest quartile of baseline dietary GI, those in the highest quartile showed an increased risk of all-cause mortality [HR = 2.15 (95% CI: 1.15-4.04); P for trend = 0.012]. In the repeated-measures analyses using as exposure the yearly updated information on GI, we observed a similar association. Dietary GL was associated with all-causemortality only when subjects were younger than 75 years. Conclusions: High dietary GI was positively associated with all-cause mortality in elderly population at high cardiovascular risk.
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https://dx.doi.org/10.1371/journal.pone.0107968MeSH
Cardiovascular DiseasesAged, 80 and over
Aged
Age Factors
Feeding Behavior
Humans
Cause of Death
Middle Aged
Dietary Carbohydrates
Diet
Male
Female
Risk Factors
Glycemic Index
Proportional Hazards Models
DeCS
Modelos de Riesgos ProporcionalesCarbohidratos de la Dieta
Femenino
Dieta
Masculino
Conducta Alimentaria
Factores de Riesgo
Humanos
Persona de Mediana Edad
Factores de Edad
Causas de Muerte
Anciano
Anciano de 80 o más Años
Enfermedades Cardiovasculares
Índice Glucémico
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Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica