How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry

Sabater, Sebastia; Berenguer, Roberto; Honrubia-Gomez, Paloma; Rivera, Miguel; Nunez, Ana; Jimenez-Jimenez, Esther; Martos, Ana; Ramirez-Castillejo, Carmen

doi:10.1093/jrr/rru022

Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11135

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URI: http://hdl.handle.net/20.500.13003/11135

DOI: 10.1093/jrr/rru022

ISSN: 0449-3060

eISSN: 1349-9157

WOS ID: 000342223100021

Scopus EID: 2-s2.0-84908155004

PMID: 24722683

Embase PUI: L605507452

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Publication date

2014-09

Document type

research article

Citation

Sabater S, Berenguer R, Honrubia-Gomez P, Rivera M, Nunez A, Jimenez-Jimenez E, et al. How air influences radiation dose deposition in multiwell culture plates: a Monte Carlo simulation of radiation geometry. J Radiat Res. 2014 Sep;55(5):1009-14. Epub 2014 Apr 10.

Abstract

Radiation of experimental culture cells on plates with various wells can cause a risk of underdosage as a result of the existence of multiple air-water interfaces. The objective of our study was to quantify this error in culture plates with multiple wells. Radiation conditions were simulated with the GAMOS code, based on the GEANT4 code, and this was compared with a simulation performed with PENELOPE and measured data. We observed a slight underdosage of similar to 4% on the most superficial half of the culture medium. We believe that this underdosage does not have a significant effect on the dose received by culture cells deposited in a monolayer and adhered to the base of the wells.