Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11184
Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study
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ISSN: 1932-6203
WOS ID: 000341307600034
Scopus EID: 2-s2.0-84905043716
PMID: 25072784
Embase PUI: L373645014
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Martinez-Gonzalez, Miguel A.; Garcia-Arellano, Ana; Toledo, Estefania; Bes-Rastrollo, Maira; Bullo, Monica; Corella, Dolores; Fito, Montserrat; Ros, Emilio; Maria Lamuela-Raventos, Rosa; Rekondo, Javier; Gomez-Gracia, Enrique; Fiol Sala, Miquel

Publication date
2014-07-29Document type
research articleCitation
Martinez-Gonzalez MA, Garcia-Arellano A, Toledo E, Bes-Rastrollo M, Bullo M, Corella D, et al. Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study. PLoS One. 2014 Jul 29;9(7):e103246.Abstract
Background: Different indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods: We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009. Results: After adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78-1.34), 1.30 (0.97-1.75) and 1.55 (1.06-2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88-1.59), 1.02 (0.74-1.41) and 1.57 (1.19-2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial. Conclusions: Our study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.
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https://dx.doi.org/10.1371/journal.pone.0103246MeSH
Cardiovascular DiseasesAged, 80 and over
Aged
Age Factors
Clinical Trials as Topic
Humans
Waist-Hip Ratio
Middle Aged
Obesity
Male
Female
Risk Factors
Proportional Hazards Models
Body Mass Index
Waist Circumference
DeCS
Índice de Masa CorporalModelos de Riesgos Proporcionales
Relación Cintura-Cadera
Femenino
Masculino
Circunferencia de la Cintura
Factores de Riesgo
Humanos
Persona de Mediana Edad
Obesidad
Factores de Edad
Anciano
Anciano de 80 o más Años
Ensayos Clínicos como Asunto
Enfermedades Cardiovasculares
This item appears in following Docusalut collections
Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica