Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11217
The Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
Identifiers
ISSN: 1932-6203
WOS ID: 000338701300120
Scopus EID: 2-s2.0-84903384930
PMID: 24925270
Embase PUI: L373399175
Share
Statistics
Item usage statisticsMetadata
Show Dublin Core item recordPublication date
2014-06-12Document type
research articleCitation
Casas R, Sacanella E, Urpi-Sarda M, Chiva-Blanch G, Ros E, Martinez-Gonzalez MA, et al. The Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial. PLoS One. 2014 Jun 12;9(6):e100084.Abstract
Background: Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. Aim: To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarkers related to atherosclerosis and plaque vulnerability in a subcohort of the PREDIMED (Prevencion con Dieta Mediterranea) study. Methods: A total of 164 participants at high risk for cardiovascular disease were randomized into three diet groups: MD supplemented with 50 mL/d of extra virgin olive oil (MD+EVOO) or 30 g/d of nuts (MD+Nuts) and a low-fat diet. Changes in classical cardiovascular risk factors, inflammatory biomarkers of atherosclerosis and plaque vulnerability were measured after 12 months of intervention. Results: Compared to participants in the low-fat diet group, those receiving MD+EVOO and MD+Nuts showed a higher decrease in systolic (6 mmHg)and diastolic (3 mmHg) blood pressure (P = 0.02; both), as well as a reduction of 10% and 8% in LDL-cholesterol (P = 0.04), respectively. Patients in the MD+Nuts group showed a significant reduction of 34% in CD40 expression on monocyte surface compared to low-fat diet patients (P = 0.03). In addition, inflammatory biomarkers related to plaque instability such as C-reactive protein and interleukin-6 were reduced by 45% and 35% and 95% and 90% in the MD+EVOO and MD+Nuts groups, respectively (P<0.05; all) compared to the low-fat diet group. Likewise, sICAM and Pselectin were also reduced by 50% and 27%, respectively in the MD+ EVOO group (P = 0.04) and P-selectin by 19% in MD+Nuts group (P = 0.04) compared to the low-fat diet group. Conclusions: Adherence to the MD is associated with an increase in serum markers of atheroma plaque stability which may explain, at least in part, the protective role of MD against ischemic heart disease.
Publisher version
https://dx.doi.org/10.1371/journal.pone.0100084MeSH
Cardiovascular DiseasesAged
CD40 Antigens
Endothelium, Vascular
Humans
C-Reactive Protein
Middle Aged
Blood Pressure
Male
Plaque, Atherosclerotic
Biomarkers
Female
Interleukin-6
Diet, Mediterranean
Intercellular Adhesion Molecule-1
P-Selectin
DeCS
Dieta MediterráneaMolécula 1 de Adhesión Intercelular
Selectina-P
Interleucina-6
Biomarcadores
Femenino
Proteína C-Reactiva
Masculino
Endotelio Vascular
Presión Sanguínea
Humanos
Persona de Mediana Edad
Anciano
Enfermedades Cardiovasculares
Placa Aterosclerótica
Antígenos CD40