Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11747
Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15-64-year-olds in Europe: exploration by birth cohort
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ISSN: 1560-7917
WOS ID: 000499654500005
Scopus EID: 2-s2.0-85076016336
PMID: 31796152
Embase PUI: L2005434356
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Kissling, Esther; Pozo, Francisco; Buda, Silke; Vilcu, Ana-Maria; Gherasim, Alin; Brytting, Mia; Domegan, Lisa; Gomez, Veronica; Meijer, Adam; Lazar, Mihaela; Vucina, Vesna Visekruna; Duerrwald, Ralf; van der Werf, Sylvie; Larrauri, Amparo; Enkirch, Theresa; O'Donnell, Joan; Guiomar, Raquel; Hooiveld, Mariette; Petrovic, Goranka; Stoian, Elena; Penttinen, Pasi; Valenciano, Marta; Preuss, Ute; Tolksdorf, Kristin; Biere, Barbara; Smallfield, Maria; Wedde, Marianne; Falchi, Alessandra; Masse, Shirley; Villechenaud, Natacha; Souty, Cecile; Blanchon, Thierry; Launay, Titouan; Enouf, Vincent; Behillil, Sylvie; Lina, Bruno; Valette, Martine; Mazagatos, Clara; Casas, Inmaculada; Garcia Comas, Luis; Insua Marisquerena, Maria Esther; Carlos Galan, Juan; Castilla, Jesus; Garcia Cenoz, Manuel; Navascues, Ana; Quinones Rubio, Carmen; Ibanez Perez, Ana Carmen; Martinez Ochoa, Eva; Blasco, Miriam; Gimenez Duran, Jaume



Publication date
2019-11-28Document type
research articleCitation
Kissling E, Pozo F, Buda S, Vilcu AM, Gherasim A, Brytting M, et al. Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15-64-year-olds in Europe: exploration by birth cohort. Eurosurveillance. 2019 Nov 28;24(48):31-42.Abstract
Introduction: Influenza A(H3N2) clades 3C.2a and 3C.3a co-circulated in Europe in 2018/19. Immunological imprinting by first childhood influenza infection may induce future birth cohort differences in vaccine effectiveness (VE). Aim: The I-MOVE multicentre primary care test-negative study assessed 2018/19 influenza A(H3N2) VE by age and genetic subgroups to explore VE by birth cohort. Methods: We measured VE against influenza A(H3N2) and (sub)clades. We stratified VE by usual age groups (0-14, 15-64, >= 65-years). To assess the imprint-regulated effect of vaccine (I-REV) hypothesis, we further stratified the middle-aged group, notably including 32-54-year-olds (1964-86) sharing potential childhood imprinting to serine at haemagglutinin position 159. Results: Influenza A(H3N2) VE among all ages was -1% (95% confidence interval (CI): -24 to 18) and 46% (95% CI: 8-68), -26% (95% CI: -66 to 4) and 20% (95% CI: -20 to 46) among 0-14, 15-64 and >= 65-year-olds, respectively. Among 15-64-year-olds, VE against clades 3C.2a1b and 3C.3a was 15% (95% CI: -34 to 50) and -74% (95% CI: -259 to 16), respectively. VE was -18% (95% CI: -140 to 41), -53% (95% CI: -131 to -2) and -12% (95% CI: -74 to 28) among 15-31-year-olds (1987-2003), 32-54-year-olds (1964-86) and 55-64-year-olds (1954-63), respectively. Discussion: The lowest 2018/19 influenza A(H3N2) VE was against clade 3C.3a and among those born 1964-86, corresponding to the I-REV hypothesis. The low influenza A(H3N2) VE in 15-64-year-olds and the public health impact of the I-REV hypothesis warrant further study.
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https://dx.doi.org/10.2807/1560-7917.ES.2019.24.48.1900604MeSH
Sentinel SurveillanceAged
Hemagglutinin Glycoproteins, Influenza Virus
Age Factors
Adult
Vaccine Potency
Humans
Adolescent
Middle Aged
Population Surveillance
Immunologic Memory
Influenza Vaccines
Male
Seasons
Europe
Influenza A Virus, H3N2 Subtype
Influenza, Human
Female
Treatment Outcome
Respiratory Tract Infections
Vaccination
DeCS
Potencia de la VacunaResultado del Tratamiento
Vacunación
Femenino
Memoria Inmunológica
Europa (Continente)
Gripe Humana
Adolescente
Vacunas contra la Influenza
Masculino
Humanos
Persona de Mediana Edad
Factores de Edad
Vigilancia de la Población
Anciano
Estaciones del Año
Vigilancia de Guardia
Adulto
Glicoproteínas Hemaglutininas del Virus de la Influenza
Subtipo H3N2 del Virus de la Influenza A
Infecciones del Sistema Respiratorio
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