Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11895
The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity
Identifiers
ISSN: 1932-6203
WOS ID: 000463992600030
Scopus EID: 2-s2.0-85064174009
PMID: 30969989
Embase PUI: L2001810587
Share
Statistics
Item usage statisticsMetadata
Show Dublin Core item recordAuthor
Gonzalez-Alvaro, Isidoro; Castrejon, Isabel; Carmona, Loreto; Dougados, M.; Huizinga, T.; Abu Shakra, M.; Alberts, A.; Alperi Lopez, M.; Amital, H.; Aringer, M.; Aslanidis, S.; Berenbaum, F.; Bijlsma, H.; Blanco Garcia, F. J.; Bliddal, H.; Borofsky, M.; Brocq, O.; Buldakov, S.; Cantini, F.; Carreno Perez, L.; Chahade, W.; Ciconelli, R.; Codreanu, C.; Dahlqvist, S. R.; Damjanov, N.; Diamantopoulos, A.; Dimdina, L.; Dimic, A.; Dorokhov, A.; Dubikov, A.; Fadienko, G.; Fano, N.; Ferreira, G.; Gabrielli, A.; Gaffney, K.; Gaudin, P.; Gerlag, D. M.; Gerli, R.; Goncalves, C. R.; Hansen, M. S.; Hanvivadhanakul, P.; Hoili, C.; Hou, A.; Hunter, J.; Ilic, T.; Ionescu, R.; Kaine, J.; Kakurina, N.; Kamalova, R.; Kelly, T.; Knyazeva, L.; Krumina, L.; Kurthen, R.; Lagrone, R. P.; Lapadula, G.; Lavrentjevs, V; Lawson, J. G.; Lazic, Z.; Lejnieks, A.; Levy, Y.; Lexberg, A.; Mader, R.; Mariette, X.; Markovits, D.; Mola, Martin E.; Maugars, Y.; Guarch, Maymo J.; Mazurov, V., I; Mikkelsen, K.; Vergles, Morovic J.; Nabizadeh, S.; Nanagara, R.; Nasonov, E. L.; Sarabia, Navarro F.; Neumann, T.; Novak, S.; Olech, E.; Oza, M.; Paran, D.; Parsik, E.; Pegram, S.; Suarez, Pombo M.; Popova, T.; Puechal, X.; Raja, N.; Ridley, D.; Rosner, I; Rubbert-Roth, A.; Rudin, A.; Saraux, A.; Saulite-Kandevica, D.; Settas, L.; Sfikakis, P.; Sheeran, T.; Sizikov, A.; Stamenkovic, D.; Stefanovic, D.; Stolow, J. B.; Tan, A. L.; Tebib, J.; Tishler, M.; Tony, H. P.; Troum, O. M.; Uaratanawong, S.; Ucar Angulo, E.; Valenzuela, G.; van der Laken, K.; Van Laar, J.; van Riel, P. L. C. M.; Vasilopoulos, D.; Veldi, T.; Vinogradova, I; Vosse, D.; Wassenberg, S.; Weidmann, C.; Weitz, M.; Wollenhaupt, J.; Xavier, R.; Yakupova, S.; Zagar, I; Zavgorodnaja, T.; Zemerova, E.; Zisman, D.; Zonova, E.; Camona, Loreto; Abasolo Alcazar, L.; Alegre de Miguel, C.; Andreu Sanchez, J. L.; Aragon Diez, A.; Balsa Criado, A.; Batlle Gualda, E.; Belmonte Serrano, M. A.; Beltran Audera, J.; Beltran Fabregat, J.; Bonilla Hernan, G.; Caro Fernandez, N.; Casado, E.; Cebrian Mendez, L.; Corteguera Coro, M.; Cuadra Diaz, J. L.; Cuesta, E.; Fiter Areste, J.; Freire Gonzalez, M.; Galindo Izquierdo, M.; Garcia Meijide, J. A.; Garcia Gomez, M. C.; Gimenez Ubeda, E.; Gomez Centeno, E.; Gomez Vaquero, C.; Gonzalez Fernandez, M. J.; Gonzalez Gomez, M. L.; Gonzalez Hernandez, T.; Gonzalez-Alvaro, I; Gonzalez-Montagut Gomez, C.; Grandal Delgado, Y.; Gratacos Masmitja, J.; Hernandez del Rio, A.; Instxaurbe, A. R.; Irigoyen Oyarzabal, M., V; Jimenez Palop, M.; Juan Mas, Antonio


Publication date
2019-04-10Document type
research articleCitation
Gonzalez-Alvaro I, Castrejon I, Carmona L, Dougados M, Huizinga T, Abu Shakra M, et al. The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity. PLoS One. 2019 Apr 10;14(4):e0214717.Abstract
Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR's.
Publisher version
https://dx.doi.org/10.1371/journal.pone.0214717MeSH
MaleSeverity of Illness Index
Arthritis, Rheumatoid
Clinical Trials as Topic
Female
Treatment Outcome
Humans
Cohort Studies
Middle Aged
Antirheumatic Agents
Linear Models
DeCS
AntirreumáticosModelos Lineales
Estudios de Cohortes
Resultado del Tratamiento
Humanos
Persona de Mediana Edad
Índice de Severidad de la Enfermedad
Ensayos Clínicos como Asunto
Femenino
Artritis Reumatoide
Masculino
This item appears in following Docusalut collections
Hospital Universitario Son Espases - HUSE > Comunicación científicaHospital Universitario Son Llàtzer - HUSLL > Comunicación científica
Related items
Showing items related by title, author, creator and subject.
-
Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial
Martinez-Gonzalez, Miguel A.; Buil-Cosiales, Pilar; Corella, Dolores; Bullo, Monica; Fito, Montserrat; [et al.] (editorial. 2019-04)