Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/11927
Enterovirus D68-associated respiratory and neurological illness in Spain, 2014?2018
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eISSN: 2222-1751
WOS ID: 000488764800001
Scopus EID: 2-s2.0-85072783840
PMID: 31571527
Embase PUI: L2003206723
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2019-01-01Document type
research articleCitation
Gonzalez-Sanz R, Taravillo I, Reina J, Navascues A, Moreno-Docon A, Aranzamendi M, et al. Enterovirus D68-associated respiratory and neurological illness in Spain, 2014?2018. Emerg Microbes Infect. 2019 Jan 01;8(1):1438-44.Abstract
During 2014, enterovirus D68 (EV-D68) outbreaks were described globally, causing severe respiratory diseases in children and, in some cases, subsequent paralysis. In this study, the type characterization of enterovirus (EV) detected in respiratory illnesses and the epidemiology and clinical association of EV-D68 infections in Spain over a five-year period were described. A total of 546 EV-positive samples from hospitalized patients with respiratory infections were included. EV-D68 was the most frequently detected type (46.6%, 191/410 typed EV). Other EV from species A (25.1%), B (27.8%) and C (0.5%) were also identified. EV-D68 infections were more associated with bronchitis while EV-A/B types were more frequent in upper respiratory illness (p < 0.01). EV-D68 was also detected in patients with neurological symptoms (nine meningitis/meningoencephalitis and eight acute flaccid paralysis cases). Phylogenetic analysis of 3?-VP1 region showed most Spanish EV-D68 sequences from 2014 to 2016 belonged to subclades B2/B3, as other American and European strains circulating during the same period. However, those detected in 2017 and 2018 clustered to the emerged subclade D1. In summary, different EV can cause respiratory infections but EV-D68 was the most prevalent, with several strains circulating in Spain at least since 2014. Association between EV-D68 infection and neurological disease was also described.
Publisher version
https://dx.doi.org/10.1080/22221751.2019.1668243Keywords
Enterovirusenterovirus D68
respiratory infections
acute flaccid paralysis
phylogenetic analysis
MeSH
Aged, 80 and overAged
Spain
Adult
Enterovirus Infections
Humans
Child, Preschool
Middle Aged
Infant
Bronchitis
Nervous System Diseases
Hospitalization
Meningitis
Phylogeny
Enterovirus D, Human
Respiratory Tract Infections
Paralysis
DeCS
LactanteEnfermedades del Sistema Nervioso
Hospitalización
Meningitis
Enterovirus Humano D
Filogenia
Bronquitis
Preescolar
Humanos
Persona de Mediana Edad
Anciano
Anciano de 80 o más Años
Parálisis
Infecciones por Enterovirus
Adulto
España
Infecciones del Sistema Respiratorio