Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/12090
Statins do not increase Markers of Cerebral Angiopathies in patients with Cardioembolic Stroke
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ISSN: 2045-2322
WOS ID: 000423154000022
Scopus EID: 2-s2.0-85041060870
PMID: 29367736
Embase PUI: L624510242
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Marti-Fabregas, Joan; Medrano-Martorell, Santiago; Merino, Elisa; Prats-Sanchez, Luis; Marin, Rebeca; Delgado-Mederos, Raquel; Camps-Renom, Pol; Martinez-Domeno, Alejandro; Gomez-Choco, Manuel; Lara, Lidia; Casado-Naranjo, Ignacio; Canovas, David; Jose Torres, Maria; Freijo, Marimar; Calleja, Ana; Bravo, Yolanda; Cocho, Dolores; Rodriguez-Campello, Ana; Zandio, Beatriz; Fuentes, Blanca; de Felipe, Alicia; Llull, Laura; Maestre, Jose; Hernandez, Maria; Garces, Moises; Maria De Arce-Borda, Ana; Palomeras, Ernest; Rodriguez-Yanez, Manuel; Diaz-Maroto, Inma; Serrano, Marta; Fernandez-Dominguez, Jessica; Sanahuja, Jordi; Purroy, Francisco; Zedde, Marialuisa; Delgado-Mengual, Jordi; Gich, IgnasiPublication date
2018-01-24Document type
research articleCitation
Marti-Fabregas J, Medrano-Martorell S, Merino E, Prats-Sanchez L, Marin R, Delgado-Mederos R, et al. Statins do not increase Markers of Cerebral Angiopathies in patients with Cardioembolic Stroke. Sci Rep. 2018 Jan 24;8:1492.Abstract
We investigated whether pre-treatment with statins is associated with surrogate markers of amyloid and hypertensive angiopathies in patients who need to start long-term oral anticoagulation therapy. A prospective multicenter study of patients naive for oral anticoagulants, who had an acute cardioembolic stroke. MRI was performed at admission to evaluate microbleeds, leukoaraiosis and superficial siderosis. We collected data on the specific statin compound, the dose and the statin intensity. We performed bivariate analyses and a logistic regression to investigate variables associated with microbleeds. We studied 470 patients (age 77.5 +/- 6.4 years, 43.7% were men), and 193 (41.1%) of them received prior treatment with a statin. Microbleeds were detected in 140 (29.8%), leukoaraiosis in 388 (82.5%) and superficial siderosis in 20 (4.3%) patients. The presence of microbleeds, leukoaraiosis or superficial siderosis was not related to pretreatment with statins. Microbleeds were more frequent in patients with prior intracerebral hemorrhage (OR 9.7, 95% CI 1.06-90.9) and in those pre-treated antiplatelets (OR 1.66, 95% CI 1.09-2.53). Prior treatment with statins was not associated with markers of bleeding-prone cerebral angiopathies in patients with cardioembolic stroke. Therefore, previous statin treatment should not influence the decision to initiate or withhold oral anticoagulation if these neuroimaging markers are detected.
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https://dx.doi.org/10.1038/s41598-018-20055-3MeSH
PrognosisAged
Male
Biomarkers
Prospective Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Female
Humans
Cerebral Hemorrhage
Intracranial Embolism
Anticoagulants
Stroke
DeCS
Embolia IntracranealHemorragia Cerebral
Inhibidores de Hidroximetilglutaril-CoA Reductasas
Accidente Cerebrovascular
Humanos
Biomarcadores
Estudios Prospectivos
Pronóstico
Anciano
Femenino
Anticoagulantes
Masculino