Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/12105
SEOM clinical guideline of diagnosis and management of low-grade glioma (2017)
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CitationSepulveda-Sanchez JM, Muñoz Langa J, Arraez MA, Fuster J, Hernandez Lain A, Reynes G, et al. SEOM clinical guideline of diagnosis and management of low-grade glioma (2017). Clin Transl Oncol. 2018 Jan;20(1):3-15. Epub 2017 Nov 9.
Diffuse infiltrating low-grade gliomas include oligodendrogliomas and astrocytomas, and account for about 5% of all primary brain tumors. Treatment strategies for these low-grade gliomas in adults have recently changed. The 2016 World Health Organization (WHO) classification has updated the definition of these tumors to include their molecular characterization, including the presence of isocitrate dehydrogenase (IDH) mutation and 1p/19p codeletion. In this new classification, the histologic subtype of grade II-mixed oligoastrocytoma has also been eliminated. The precise optimal management of patients with low-grade glioma after resection remains to be determined. The risk-benefit ratio of adjuvant treatment must be weighed for each individual.