Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/12398
The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
Identifiers
DOI: 10.3390/nu12010048
eISSN: 2072-6643
WOS ID: 000516825500048
Scopus EID: 2-s2.0-85077310957
PMID: 31878004
Embase PUI: L2003420862
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Carlos Flores, Jose; Gracia-Lavedan, Esther; Benavente, Yolanda; Amiano, Pilar; Romaguera, Dora

Publication date
2020-01Document type
research articleCitation
Flores JC, Gracia-Lavedan E, Benavente Y, Amiano P, Romaguera D, Costas L, et al. The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study. Nutrients. 2020 Jan;12(1):48.Abstract
Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII (R)) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR (T3vsT1): 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.
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https://dx.doi.org/10.3390/nu12010048Keywords
dietary inflammatory indexchronic lymphocytic leukaemia
case-control study
MCC Spain study
nutrition
cancer
MeSH
AgedCase-Control Studies
Energy Intake
Spain
Humans
Inflammation
Middle Aged
Diet
Male
Severity of Illness Index
Female
Risk Factors
Odds Ratio
Leukemia, Lymphocytic, Chronic, B-Cell
Diet Records
DeCS
Registros de DietaOportunidad Relativa
Femenino
Dieta
Masculino
Factores de Riesgo
Humanos
Persona de Mediana Edad
Ingestión de Energía
Inflamación
Anciano
Índice de Severidad de la Enfermedad
Leucemia Linfocítica Crónica de Células B
España
Estudios de Casos y Controles