Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/12834
Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study)
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AuthorTorres, Armando; Torregrosa, Vicens; Marcen, Roberto; Maria Campistol, Josep; Arias, Manuel; Hernandez, Domingo; Fernandez, Constantino; Esforzado, Nuria; Paschoalin, Raphael; Perez, Nuria; Isabel Garcia, Ana; Del Amo, Montserrat; Pomes, Jaume; Gonzalez Rinne, Ana; Marrero, Domingo; Pereza, Estefania; Henriquez, Fernando; Manuel Diaz, Juan; Silva, Irene; Lopez, Veronica; Perello, Manuel; Ramos, David; Beneyto, Isabel; Maria Cruzado, Jose; Martinez Castelaok, Alberto; Bravo, Juan; Rodriguez, Minerva; Diaz, Carmen; Crespo, Josep; Anaya, Fernando; Luisa Rodriguezo, Maria; Jose Cubero, Juan; Pascual, Pilar; Romero, Rafael; Andres Belmonte, Amado; Dolores Checa, Maria; Jimenez, Carlos; Escuin, Fernando; Crespo, Marta; Mir, Marisa; Gomez, Gonzalo; Bayes, Beatriz; Jose Gonzalez, Maria; Gutierrez, Alex; Cuberes, Marta; Rodriguez Benoit, Alberto; Garcia, Teresa; Llamas, Francisco; Ortega, Agustin; Luis Conde, Jose; Gomez Alamillo, Carlos
Document typeresearch article
CitationTorres A, Torregrosa Vi, Marcen R, Campistol JM, Arias M, Hernandez D, et al. Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study). Nefrologia. 2016 May;36(3):255-67. Epub 2016 Apr 28.
Background and objectives: The relationship between mineral metabolism disorders, bone fractures and vascular calcifications in kidney transplant recipients has not been established. Method: We performed a cross-sectional study in 727 stable recipients from 28 Spanish transplant clinics. Mineral metabolism parameters, the semi-quantification of vertebral fractures and abdominal aortic calcifications were determined centrally. Results: Vitamin D deficiency (250HD(3) <15 ng/ml) was more common in female recipients at CKD-T stages I-III (29.6% vs 44.4%; p = 0.003). The inverse and significant correlation between 250HD(3) and PTH was gender-specific and women exhibited a steeper slope than men (p = 0.01). Vertebral fractures (VFx) with deformity grade >= 2 were observed in 15% of recipients. Factors related to VFx differed by gender; in males, age (OR 1.04; 95% CI 1.01-1.06) and CsA treatment (OR: 3.2; 95% CI: 1.6-6.3); in females, age (OR 1.07; 95% CI: 1.03-1.12) and PTH levels (OR per 100 pg/ml increase: 1.27; 95% CI: 1.043-1.542). Abdominal aortic calcifications were common (67.2%) and related to classical risk factors but not to mineral metabolism parameters. Conclusions: Vitamin D deficiency is more common among female kidney transplant recipients at earlier CKD-T stages, and it contributes to secondary hyperparathyroidism. Prevalent vertebral fractures are only related to high serum PTH levels in female recipients.
Vitamin D deficiency
This item appears in following Docusalut collectionsHospital Universitario Son Espases - HUSE > Comunicación científica
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