Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/13042
Experience-dependent neuroplasticity in trained musicians modulates the effects of chronic pain on insula-based networks - A resting-state fMRI study
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ISSN: 1053-8119
eISSN: 1095-9572
WOS ID: 000491861000036
Scopus EID: 2-s2.0-85071375545
PMID: 31437550
Embase PUI: L2002723065
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2019-11-15Document type
research articleCitation
Zamorano Andres Ana Maria, Montoya Pedro, Cifre Leon Ignacio, Vuust Peter, Riquelme Inmaculada, Kleber Boris. Experience-dependent neuroplasticity in trained musicians modulates the effects of chronic pain on insula-based networks - A resting-state fMRI study. Neuroimage. 2019 Nov 15;202:116103. Epub 2019 Aug 19.Abstract
Recent resting-state fMRI studies associated extensive musical training with increased insula-based connectivity in large-scale networks involved in salience, emotion, and higher-order cognitive processes. Similar changes have also been found in chronic pain patients, suggesting that both types of experiences can have comparable effects on insula circuitries. Based on these observations, the current study asked the question whether, and if so in what way, different forms of experience-dependent neuroplasticity may interact. Here we assessed insula-based connectivity during fMRI resting-state between musicians and non-musicians both with and without chronic pain, and correlated the results with clinical pain duration and intensity. As expected, insula connectivity was increased in chronic pain non-musicians relative to healthy non-musicians (with cingulate cortex and supplementary motor area), yet no differences were found between chronic pain non-musicians and healthy musicians. In contrast, musicians with chronic pain showed decreased insula connectivity relative to both healthy musicians (with sensorimotor and memory regions) and chronic pain non-musicians (with the hippocampus, inferior temporal gyrus, and orbitofrontal cortex), as well as lower pain-related inferences with daily activities. Pain duration correlated positively with insula connectivity only in non-musicians, whereas pain intensity exhibited distinct relationships across groups. We conclude that although music-related sensorimotor training and chronic pain, taken in isolation, can lead to increased insula-based connectivity, their combination may lead to higher-order plasticity (metaplasticity) in chronic pain musicians, engaging brain mechanisms that can modulate the consequences of maladaptive experience-dependent neural reorganization (i.e., pain chronification).
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https://dx.doi.org/10.1016/j.neuroimage.2019.116103Keywords
Experience-dependent neuroplasticityInsula
Musicians
Chronic pain
Resting-state fMRI
Sensorimotor training
MeSH
Brain MappingMusic
Male
Neuronal Plasticity
Adult
Female
Humans
Chronic Pain
Nerve Net
Magnetic Resonance Imaging
Cerebral Cortex
DeCS
Corteza CerebralHumanos
Dolor Crónico
Red Nerviosa
Mapeo Encefálico
Femenino
Música
Imagen por Resonancia Magnética
Adulto
Masculino
Plasticidad Neuronal