Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/13065
VIM-2-producing Multidrug-Resistant Pseudomonas aeruginosa ST175 Clone, Spain
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ISSN: 1080-6040
eISSN: 1080-6059
WOS ID: 000307209800002
Scopus EID: 2-s2.0-84864487092
PMID: 22840969
Embase PUI: L365350715
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2012-08Document type
research articleCitation
Viedma E, Juan C, Villa J, Barrado L, Orellana MA, Sanz F, et al. VIM-2-producing Multidrug-Resistant Pseudomonas aeruginosa ST175 Clone, Spain. Emerg Infect Dis. 2012 Aug;18(8):1235-41.Abstract
A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the b/a(VIM-2) gene in all but 1 isolate, which harbored b/a(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P aeruginosa nosocomial infections.
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https://dx.doi.org/10.3201/eid1808.111234MeSH
GenotypeAged
Bacterial Typing Techniques
Drug Resistance, Multiple, Bacterial
Spain
Anti-Bacterial Agents
Cross Infection
Microbial Sensitivity Tests
DNA, Bacterial
Humans
Middle Aged
Male
Multilocus Sequence Typing
Female
beta-Lactamases
Pseudomonas aeruginosa
Prevalence
Sequence Analysis, DNA
Molecular Epidemiology
Pseudomonas Infections
DeCS
Epidemiología MolecularAnálisis de Secuencia de ADN
Farmacorresistencia Bacteriana Múltiple
Prevalencia
Femenino
Masculino
Pruebas de Sensibilidad Microbiana
Humanos
Persona de Mediana Edad
ADN Bacteriano
Anciano
Infección Hospitalaria
Genotipo
Infecciones por Pseudomonas
Pseudomonas aeruginosa
Antibacterianos
beta-Lactamasas
Tipificación de Secuencias Multilocus
España
Técnicas de Tipificación Bacteriana