Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/13319
Breast Milk Supply of MicroRNA Associated with Leptin and Adiponectin Is Affected by Maternal Overweight/Obesity and Influences Infancy BMI
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DOI: 10.3390/nu11112589
eISSN: 2072-6643
WOS ID: 000502274600040
Scopus EID: 2-s2.0-85074262619
PMID: 31661820
Embase PUI: L2002884602
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2019-11Document type
research articleCitation
Zamanillo R, Sánchez J, Serra F, Palou Oliver A. Breast Milk Supply of MicroRNA Associated with Leptin and Adiponectin Is Affected by Maternal Overweight/Obesity and Influences Infancy BMI. Nutrients. 2019 Nov;11(11):2589.Abstract
Breast milk constitutes a dietary source of leptin, adiponectin and microRNAs (miRNAs) for newborns. Expression of miRNAs previously associated with maternal obesity, leptin or adiponectin function were assessed and their impact on infant weight analyzed. Milk samples were collected (at month 1, 2, and 3) from a cohort of 59 healthy lactating mothers (38 normal-weight and 21 overweight/obese (BMI >= 25)), and infant growth was followed up to 2 years of age. Thirteen miRNAs, leptin and adiponectin were determined in milk. Leptin, adiponectin and miRNA showed a decrease over time of lactation in normal-weight mothers that was altered in overweight/obesity. Furthermore, negative correlations were observed in normal-weight mothers between the expression of miRNAs in milk and the concentration of leptin or adiponectin, but were absent in overweight/obesity. Moreover, miRNAs negatively correlated with infant BMI only in normal-weight mothers (miR-103, miR-17, miR-181a, miR-222, miR-let7c and miR-146b). Interestingly, target genes of milk miRNAs differently regulated in overweight/obesity could be related to neurodevelopmental processes. In conclusion, a set of miRNAs present in breast milk, in close conjunction with leptin and adiponectin, are natural bioactive compounds with the potential to modulate infant growth and brain development, an interplay that is disturbed in the case of maternal overweight/obesity.
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https://dx.doi.org/10.3390/nu11112589MeSH
PregnancyBreast Feeding
MicroRNAs
Adiponectin
Leptin
Female
Body Mass Index
Gene Expression Regulation
Humans
Overweight
Obesity, Maternal
Milk, Human
DeCS
Índice de Masa CorporalRegulación de la Expresión Génica
Humanos
Embarazo
Lactancia Materna
Femenino
Obesidad Materna
Leche Humana
Leptina
Adiponectina
Sobrepeso
MicroARNs