Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15251
Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
Identifiers
ISSN: 0025-7974
eISSN: 1536-5964
WOS ID: 000377777700023
Scopus EID: 2-s2.0-84973444336
PMID: 27227930
Embase PUI: L610735053
Share
Statistics
Item usage statisticsMetadata
Show Dublin Core item recordPublication date
2016-05Document type
research articleCitation
Moya P, Soriano-Irigaray L, Ramirez JM, Garcea A, Blasco O, Blanco FJ, et al. Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study). Medicine (Baltimore). 2016 May;95(21):e3704.Abstract
To compare immunonutrition versus standard high calorie nutrition in patients undergoing elective colorectal resection within an Enhanced Recovery After Surgery (ERAS) program.Despite progress in recent years in the surgical management of patients with colorectal cancer (ERAS programs), postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the extent to which the combination of ERAS protocols and immunonutrition benefits patients undergoing colorectal cancer surgery is unknown.The SONVI study is a prospective, multicenter, randomized trial with 2 parallel treatment groups receiving either the study product (an immune-enhancing feed) or the control supplement (a hypercaloric hypernitrogenous supplement) for 7 days before colorectal resection and 5 days postoperatively.A total of 264 patients were randomized. At baseline, both groups were comparable in regards to age, sex, surgical risk, comorbidity, and analytical and nutritional parameters. The median length of the postoperative hospital stay was 5 days with no differences between the groups. A decrease in the total number of complications was observed in the immunonutrition group compared with the control group, primarily due to a significant decrease in infectious complications (23.8% vs. 10.7%, P=0.0007). Of the infectious complications, wound infection differed significantly between the groups (16.4% vs. 5.7%, P=0.0008). Other infectious complications were lower in the immunonutrition group but were not statistically significantly different.The implementation of ERAS protocols including immunonutrient-enriched supplements reduces the complications of patients undergoing colorectal resection.This study is registered with ClinicalTrial.gov: NCT02393976.
Publisher version
https://dx.doi.org/10.1097/MD.0000000000003704MeSH
Aged, 80 and overPerioperative Care
Aged
Clinical Protocols
Colorectal Surgery
Spain
Adult
Length of Stay
Humans
Middle Aged
Male
Prospective Studies
Female
Colorectal Neoplasms
Postoperative Complications
Dietary Supplements
Surgical Wound Infection
DeCS
Complicaciones PosoperatoriasNeoplasias Colorrectales
Infección de la Herida Quirúrgica
Femenino
Masculino
Tiempo de Internación
Humanos
Persona de Mediana Edad
Protocolos Clínicos
Estudios Prospectivos
Anciano
Atención Perioperativa
Anciano de 80 o más Años
Cirugía Colorrectal
Adulto
Suplementos Dietéticos
España