Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15513
Association between markers of glycemia and carotid intima-media thickness: the MARK study
Identifiers
ISSN: 1471-2261
WOS ID: 000386444200001
Scopus EID: 2-s2.0-84992677674
PMID: 27793100
Embase PUI: L612941739
Share
Statistics
Item usage statisticsMetadata
Show Dublin Core item recordPublication date
2016-10-28Document type
research articleCitation
Gomez-Marcos MA, Gomez-Sanchez L, Patino-Alonso MC, Recio-Rodriguez JI, Garcia Regalado N, Ramos R, et al. Association between markers of glycemia and carotid intima-media thickness: the MARK study. BMC Cardiovasc Disord. 2016 Oct 28;16:203.Abstract
Background: Carotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients. Methods: This study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 +/- 8.5 years), 55 % women, enrolled into the MARK study. Including 231 subjects defined as normal glucose, 104 subjects classified as prediabetes and 92 with type 2 diabetes mellitus. Carotid ultrasound was used to measure C-IMT and the presence of plaques. Fasting plasma glucose (mg/dl) and glycated hemoglobin (%) (HbA1c) were measured using standard enzymatic automated methods. Postprandial glucose (mg/dl) was self-measured by patients at home 2 h after meals (breakfast, lunch and dinner) for 1 day. Results: The C-IMT shows a positive correlation with fasting plasma glucose, postprandial glucose and HbA1c. Multiple linear regression analysis showed a positive association between HbA1c and C-IMT, with a 0.016 mm and 0.019 mm increase in mean and maximum C-IMT per 1 % increase in HbA1c. In addition, an association between fasting plasma glucose and C-IMT was found with an increase of 0.004 and 0.005 mm in mean and maximum C-IMT per 10 mg/dl in fasting plasma glucose. We also observed a graded association between fasting plasma glucose, postprandial glucose and HbA1c and the presence of carotid target organ damage (TOD), with an odds ratio of 1.013, 1.010 and 1.425, respectively. Conclusion: The results of this study suggest that the fasting plasma glucose and HbA1c, but not postprandial glucose, are associated with C-IMT media and maximum. The patients who present with a metabolic glucose alteration have more risk of developing carotid TOD.
Publisher version
https://dx.doi.org/10.1186/s12872-016-0380-6MeSH
Cardiovascular DiseasesAged
Blood Glucose
Spain
Adult
Carotid Arteries
Follow-Up Studies
Forecasting
Glucose Tolerance Test
Humans
Middle Aged
Cross-Sectional Studies
Glycated Hemoglobin A
Prediabetic State
Male
Biomarkers
Carotid Intima-Media Thickness
Female
Risk Factors
Prevalence
Incidence
DeCS
IncidenciaPrevalencia
Biomarcadores
Femenino
Hemoglobina A Glucada
Masculino
Estudios de Seguimiento
Predicción
Prueba de Tolerancia a la Glucosa
Estudios Transversales
Factores de Riesgo
Humanos
Persona de Mediana Edad
Glucemia
Estado Prediabético
Anciano
Grosor Intima-Media Carotídeo
Enfermedades Cardiovasculares
Arterias Carótidas
Adulto
España