Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15555
Improving interMediAte Risk management. MARK study
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ISSN: 1471-2261
WOS ID: 000296611600001
Scopus EID: 2-s2.0-80053908085
PMID: 21992621
Embase PUI: L51670545
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2011-10-13Document type
research articleCitation
Marti R, Parramon D, Garcia-Ortiz L, Rigo F, Gomez-Marcos MA, Sempere I, et al. Improving interMediAte Risk management. MARK study. BMC Cardiovasc Disord. 2011 Oct 13;11:61.Abstract
Background: Cardiovascular risk functions fail to identify more than 50% of patients who develop cardiovascular disease. This is especially evident in the intermediate-risk patients in which clinical management becomes difficult. Our purpose is to analyze if ankle-brachial index (ABI), measures of arterial stiffness, postprandial glucose, glycosylated hemoglobin, self-measured blood pressure and presence of comorbidity are independently associated to incidence of vascular events and whether they can improve the predictive capacity of current risk equations in the intermediate-risk population. Methods/Design: This project involves 3 groups belonging to REDIAPP (RETICS RD06/0018) from 3 Spanish regions. We will recruit a multicenter cohort of 2688 patients at intermediate risk (coronary risk between 5 and 15% or vascular death risk between 3-5% over 10 years) and no history of atherosclerotic disease, selected at random. We will record socio-demographic data, information on diet, physical activity, comorbidity and intermittent claudication. We will measure ABI, pulse wave velocity and cardio ankle vascular index at rest and after a light intensity exercise. Blood pressure and anthropometric data will be also recorded. We will also quantify lipids, glucose and glycosylated hemoglobin in a fasting blood sample and postprandial capillary glucose. Eighteen months after the recruitment, patients will be followed up to determine the incidence of vascular events (later follow-ups are planned at 5 and 10 years). We will analyze whether the new proposed risk factors contribute to improve the risk functions based on classic risk factors. Discussion: Primary prevention of cardiovascular diseases is a priority in public health policy of developed and developing countries. The fundamental strategy consists in identifying people in a high risk situation in which preventive measures are effective and efficient. Improvement of these predictions in our country will have an immediate, clinical and welfare impact and a short term public health effect.
Publisher version
https://dx.doi.org/10.1186/1471-2261-11-61MeSH
Blood Pressure Monitoring, AmbulatoryCardiovascular Diseases
Disease Progression
Aged
Blood Glucose
Spain
Adult
Risk Assessment
Follow-Up Studies
Humans
Risk Adjustment
Middle Aged
Prognosis
Male
Female
Risk Factors
Ankle Brachial Index
Cohort Studies
Survival Analysis
Comorbidity
DeCS
Estudios de CohortesComorbilidad
Ajuste de Riesgo
Análisis de Supervivencia
Femenino
Masculino
Estudios de Seguimiento
Factores de Riesgo
Índice Tobillo Braquial
Humanos
Persona de Mediana Edad
Glucemia
Pronóstico
Anciano
Medición de Riesgo
Progresión de la Enfermedad
Enfermedades Cardiovasculares
Adulto
Monitoreo Ambulatorio de la Presión Arterial
España