Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15663
Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers
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ISSN: 1932-6203
WOS ID: 000358197600107
Scopus EID: 2-s2.0-84941309181
PMID: 26177462
Embase PUI: L605951876
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Pont-Sunyer, Claustre; Iranzo, Alex; Gaig, Carles; Fernandez-Arcos, Ana; Vilas, Dolores; Valldeoriola, Francesc; Compta, Yaroslau; Fernandez-Santiago, Ruben; Fernandez, Manel; Bayes, Angels; Calopa, Matilde; Casquero, Pilar; de Fabregues, Oriol; Jauma, Serge; Puente, Victor; Salamero, Manel; Marti, Maria Jose; Santamaria, Joan; Tolosa, EduardPublication date
2015-07-15Document type
research articleCitation
Pont-Sunyer C, Iranzo A, Gaig C, Fernandez-Arcos A, Vilas D, Valldeoriola F, et al. Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers. PLoS One. 2015 Jul 15;10(7):e0132368.Abstract
Objective In idiopathic Parkinson disease (IPD) sleep disorders are common and may antedate the onset of parkinsonism. Based on the clinical similarities between IPD and Parkinson disease associated with LRRK2 gene mutations (LRRK2-PD), we aimed to characterize sleep in parkinsonian and nonmanifesting LRRK2 mutation carriers (NMC). Methods A comprehensive interview conducted by sleep specialists, validated sleep scales and questionnaires, and video-polysomnography followed by multiple sleep latency test (MSLT) assessed sleep in 18 LRRK2-PD (17 carrying G2019S and one R1441G mutations), 17 NMC (11 G2019S, three R1441G, three R1441C), 14 non-manifesting non-carriers (NMNC) and 19 unrelated IPD. Results Sleep complaints were frequent in LRRK2-PD patients; 78% reported poor sleep quality, 33% sleep onset insomnia, 56% sleep fragmentation and 39% early awakening. Sleep onset insomnia correlated with depressive symptoms and poor sleep quality. In LRRK2-PD, excessive daytime sleepiness (EDS) was a complaint in 33% patients and short sleep latencies on the MSLT, which are indicative of objective EDS, were found in 71%. Sleep attacks occurred in three LRRK2-PD patients and a narcoleptic phenotype was not observed. REM sleep behavior disorder (RBD) was diagnosed in three LRRK2-PD. EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. In NMC, EDS was rarely reported and RBD was absent. When compared to IPD, sleep onset insomnia was more significantly frequent, EDS was similar, and RBD was less significantly frequent and less severe in LRRK2-PD. In NMC, RBD was not detected and sleep complaints were much less frequent than in LRRK2-PD. No differences were observed in sleep between NMC and NMNC. Conclusions Sleep complaints are frequent in LRRK2-PDand show a pattern that when compared to IPD is characterized by more frequent sleep onset insomnia, similar EDS and less prominent RBD. Unlike in IPD, RBD and EDS seem to be not markers of the prodromal stage of LRRK2-PD.
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https://dx.doi.org/10.1371/journal.pone.0132368MeSH
REM Sleep Behavior DisorderPolysomnography
Adult
Electromyography
Humans
Demography
Heterozygote
Middle Aged
Parkinson Disease
Male
Restless Legs Syndrome
Mutation
Female
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Protein-Serine-Threonine Kinases
Sleep Wake Disorders
DeCS
Proteínas Serina-Treonina QuinasasTrastornos del Sueño-Vigilia
Trastorno de la Conducta del Sueño REM
Femenino
Mutación
Masculino
Electromiografía
Demografía
Humanos
Persona de Mediana Edad
Heterocigoto
Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina
Enfermedad de Parkinson
Síndrome de las Piernas Inquietas
Adulto
Polisomnografía