Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15736
Prenatal Concentrations of Polychlorinated Biphenyls, DDE, and DDT and Overweight in Children: A Prospective Birth Cohort Study
Identifiers
DOI: 10.1289/ehp.1103862
ISSN: 0091-6765
eISSN: 1552-9924
WOS ID: 000301394700036
Scopus EID: 2-s2.0-84857738193
PMID: 22027556
Embase PUI: L364366014
Share
Statistics
Item usage statisticsMetadata
Show Dublin Core item recordPublication date
2012-03Document type
research articleCitation
Valvi D, Mendez MA, Martinez D, Grimalt JO, Torrent M, Sunyer J, et al. Prenatal Concentrations of Polychlorinated Biphenyls, DDE, and DDT and Overweight in Children: A Prospective Birth Cohort Study. Environ Health Perspect. 2012 Mar;120(3):451-7. Epub 2011 Oct 25.Abstract
BACKGROUND: Recent experimental evidence suggests that prenatal exposure to endocrine-disrupting chemicals (EDCs) may increase postnatal obesity risk and that these effects may be sex or diet dependent. OBJECTIVES: We explored whether prenatal organochlorine compound (OC) concentrations [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and dichlorodiphenyltrichloroethane (DDT)] were associated with overweight at 6.5 years of age and whether child sex or fat intakes modified these associations. METHODS: We studied 344 children from a Spanish birth cohort established in 1997-1998. Overweight at 6.5 years was defined as a body mass index (BMI) z-score >= 85th percentile of the World Health Organization reference. Cord blood OC concentrations were measured and treated as categorical variables (tertiles). Children's diet was assessed by food frequency questionnaire. Relative risks (RRs) were estimated using generalized linear models. RESULTS: After multivariable adjustment, we found an increased RR of overweight in the third tertile of PCB exposure [RR = 1.70; 95% confidence interval (Cl): 1.09, 2.64] and the second tertile of DDE exposure (RR = 1.67; 95% CI: 1.10, 2.55), but no association with DDT exposure in the population overall. Associations between overweight and PCB and DDE concentrations were strongest in girls (p-interaction between 0.01 and 0.28); DDT was associated with overweight only in boys. For DDT we observed stronger associations in children with fat intakes at or above compared with below the median, but this interaction was not significant (p-interaction > 0.05). CONCLUSIONS: This study suggests that prenatal OC exposures may be associated with overweight in children and that sex and high-fat intake may influence susceptibility.
Publisher version
https://dx.doi.org/10.1289/ehp.1103862Keywords
body mass indexdichlorodiphenyldichloroethylene (DDE)
dichlorodiphenyltrichlomethane (DDT)
environmental obesogens
high-fat intakes
obesity
persistent organic pollutants
polychlorinated biphenyls (PCBs)
MeSH
ChildChromatography, Gas
DDT
Spain
Adult
Humans
Dichlorodiphenyl Dichloroethylene
Fetal Blood
Obesity
Dietary Fats
Pregnancy
Pesticides
Hexachlorobenzene
Male
Prospective Studies
Sex Factors
Female
Risk Factors
Body Mass Index
Cohort Studies
Overweight
Polychlorinated Biphenyls
Prenatal Exposure Delayed Effects
Prevalence
DeCS
Índice de Masa CorporalEstudios de Cohortes
Prevalencia
Hexaclorobenceno
Femenino
Grasas de la Dieta
Masculino
Sangre Fetal
Factores Sexuales
Factores de Riesgo
Diclorodifenil Dicloroetileno
DDT
Humanos
Obesidad
Estudios Prospectivos
Embarazo
Plaguicidas
Niño
Bifenilos Policlorados
Adulto
Efectos Tardíos de la Exposición Prenatal
Sobrepeso
España
Cromatografía de Gases