Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15752
Genetic Variants of the FADS Gene Cluster and ELOVL Gene Family, Colostrums LC-PUFA Levels, Breastfeeding, and Child Cognition
Identifiers
ISSN: 1932-6203
WOS ID: 000287657500039
Scopus EID: 2-s2.0-79952010953
PMID: 21383846
Embase PUI: L361332458
Share
Statistics
Item usage statisticsMetadata
Show Dublin Core item recordPublication date
2011-02-23Document type
research articleCitation
Morales E, Bustamante M, Ramon Gonzalez J, Guxens M, Torrent M, Mendez M, et al. Genetic Variants of the FADS Gene Cluster and ELOVL Gene Family, Colostrums LC-PUFA Levels, Breastfeeding, and Child Cognition. PLoS One. 2011 Feb 23;6(2):e17181.Abstract
Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children's Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes.
Publisher version
https://dx.doi.org/10.1371/journal.pone.0017181MeSH
Breast FeedingAdult
Child Development
Fatty Acid Desaturases
Humans
Child, Preschool
Colostrum
Multigene Family
Acetyltransferases
Infant
Cognition Disorders
Fatty Acids, Unsaturated
Male
Infant, Newborn
Female
Cognition
Cohort Studies
Genetic Variation
Fatty Acid Elongases
DeCS
Ácido Graso DesaturasasEstudios de Cohortes
Variación Genética
Cognición
Recién Nacido
Trastornos del Conocimiento
Femenino
Lactante
Ácidos Grasos Insaturados
Elongasas de Ácidos Grasos
Masculino
Preescolar
Acetiltransferasas
Humanos
Familia de Multigenes
Calostro
Lactancia Materna
Desarrollo Infantil
Adulto