Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15833
Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age
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DOI: 10.1289/ehp.9314
ISSN: 0091-6765
eISSN: 1552-9924
WOS ID: 000244651500040
Scopus EID: 2-s2.0-34147105613
PMID: 17431497
Embase PUI: L46554446
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2007-03Document type
research articleCitation
Ribas-Fito N, Torrent M, Carrizo D, Julvez J, Grimalt JO, Sunyer J. Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age. Environ Health Perspect. 2007 Mar;115(3):447-50. Epub 2006 Nov 6.Abstract
BACKGROUND: Hexachlorobenzene (HCB) is an organochlorine chemical that has been used in agriculture and industrial processes. Behavioral impairment after HCB exposure has been described if animal models, but little information is available in humans. OBJECTIVES: Our goal was to study the association of prenatal exposure to HCB with the social behavior of preschool children. METHODS: Two birth cohorts in Ribera d'Ebre and Menorca (Spain) were set up between 1997 and 1199 (n = 475). The California Preschool Social Competence Scale and the Attention-Deficit hyperactivity Disorder (ADHD) were scored by each 4-year-old child's teacher. Organochlorine compounds were measured in cord serum. Children's diet and parental sociodemographic information were obtained through questionnaire. RESULTS: Children with concentrations of HCB > 1.5 ng/mL at birth had a statistically significant increased risk of having poor Social Competence [relative risk (RR) = 4.04; 95% confidence interval (CI), 1.76-9.58] and ADHD (RR = 2.71; 95% CI, 1.05-6.96) scores. No association was found between HCB and the cognitive and psychomotor performance of these children. CONCLUSIONS: Prenatal exposure to current concentrations of HCB in Spain is associated with a decrease in the behavioral competence at preschool ages. These results should be considered when evaluating the potential neurotoxicologic effects of HCB.
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https://dx.doi.org/10.1289/ehp.9314Keywords
behaviorchildren
cord serum
HCB
hexachlorobenzene
hyperactivity
prenatal exposure
social competence
MeSH
SpainAdult
Follow-Up Studies
Humans
Air Pollutants
Child, Preschool
Attention Deficit Disorder with Hyperactivity
Epidemiological Monitoring
Environmental Monitoring
Fetal Blood
Social Behavior
Pregnancy
Maternal-Fetal Exchange
Hexachlorobenzene
Female
Maternal Exposure
Prenatal Exposure Delayed Effects
DeCS
Exposición MaternaHexaclorobenceno
Femenino
Intercambio Materno-Fetal
Monitoreo Epidemiológico
Contaminantes Atmosféricos
Monitoreo del Ambiente
Estudios de Seguimiento
Sangre Fetal
Conducta Social
Trastorno por Déficit de Atención con Hiperactividad
Preescolar
Humanos
Embarazo
Adulto
Efectos Tardíos de la Exposición Prenatal
España