Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15855
Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children
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DOI: 10.1289/ehp.8127
ISSN: 0091-6765
eISSN: 1552-9924
WOS ID: 000233713200054
Scopus EID: 2-s2.0-29144495989
PMID: 16330365
Embase PUI: L41794278
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2005-12Document type
research articleCitation
Sunyer J, Torrent M, Muñoz-Ortiz L, Ribas-Fito N, Carrizo D, Grimalt J, et al. Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children. Environ Health Perspect. 2005 Dec;113(12):1787-90.Abstract
Prevalence of asthma increases with increasing dichlorodiphenyldichloroethylene (DDE) levels. However, the effect of early-life exposure, the fundamental window of exposure, is unknown. We assessed the association between prenatal DDE and other organochlorine compounds, and atopy and asthma during infancy. All women presenting for antenatal care in Menorca (Spain) over 12 months starting in mid-1997 were invited to take part in a longitudinal study; 482 children were subsequently enrolled, and 468 (97.1%) provided complete outcome data up to the fourth year of study. Prenatal exposure of organochlorine compounds was measured in cord serum in 405 (83%) children. Asthma was defined on the basis of wheezing at 4 years of age, persistent wheezing, or doctor-diagnosed asthma. We measured specific immunoglobulin-E (IgE) against house dust mite, cat, and grass in sera extracted at 4 years of age. DDE (median=1.03 ng/mL) was detected in all children, as well as hexachlorobenzene (0.68 ng/mL) and polychlorobiphenyls (0.69 ng/mL). Wheezing at 4 years of age increased with DDE concentration, particularly at the highest quartile [9% in the lowest quartile (<0.57 ng/mL) vs. 19% in the highest quartile (1.90 ng/mL); relative risk=2.63 (95% confidence interval 1.19-4.69), adjusting for maternal asthma, breast-feeding, education, social class, or other organochlorines]. The association was not modified by IgE sensitization and occurred with the same strength among nonatopic subjects and among those with persistent wheezing or diagnosed asthma. DDE was not associated with atopy alone. Prenatal exposure to DDE residues may contribute to development of asthma.
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https://dx.doi.org/10.1289/ehp.8127MeSH
AntigensAsthma
Dose-Response Relationship, Drug
Spain
Humans
Child, Preschool
Dichlorodiphenyl Dichloroethylene
Fetal Blood
Infant
Longitudinal Studies
Pregnancy
Hexachlorobenzene
Male
Infant, Newborn
Female
Immunoglobulin E
Polychlorinated Biphenyls
Respiratory Sounds
Prenatal Exposure Delayed Effects
DeCS
HexaclorobencenoRecién Nacido
Femenino
Lactante
Inmunoglobulina E
Masculino
Sangre Fetal
Preescolar
Diclorodifenil Dicloroetileno
Estudios Longitudinales
Relación Dosis-Respuesta a Droga
Humanos
Embarazo
Antígenos
Asma
Ruidos Respiratorios
Bifenilos Policlorados
Efectos Tardíos de la Exposición Prenatal
España