Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15935
Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere Disease
StatisticsItem usage statistics
MetadataShow Dublin Core item record
AuthorGallego-Martinez, Alvaro; Requena, Teresa; Roman-Naranjo, Pablo; Lopez-Escamez, Jose A.; Amor-Dorado, Juan Carlos; Aran, Ismael; Batuecas-Caletrio, Angel; Benitez, Jesus; Fraile, Jesus; Garcia-Arumi, Ana; Gonzalez-A, Rocio; Espinosa-Sanchez, Juan M.; Manrique Huarte, Raquel; Perez-Fernandez, Nicolas; Marques, Pedro; Sanz, Ricardo; Oliva Dominguez, Manuel; Teggi, Roberto; Meniere Dis Consortium MeDiC
Document typeresearch article
CitationGallego-Martinez A, Requena T, Roman-Naranjo P, Lopez-Escamez JA, Amor-Dorado JC, Aran I, et al. Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere Disease. Front Genet. 2019 Feb 15;10:76.
Meniere's disease (MD) is a clinical spectrum of rare disorders characterized by vertigo attacks, associated with sensorineural hearing loss (SNHL) and tinnitus involving low to medium frequencies. Although it shows familial aggregation with incomplete phenotypic forms and variable expressivity, most cases are considered sporadic. The aim of this study was to investigate the burden for rare variation in SNHL genes in patients with sporadic MD. We conducted a targeted-sequencing study including SNHL and familial MD genes in 890 MD patients to compare the frequency of rare variants in cases using three independent public datasets as controls. Patients with sporadic MD showed a significant enrichment of missense variants in SNHL genes that was not found in the controls. The list of genes includes GJB2, USH1G, SLC26A4, ESRRB, and CLDN14. A rare synonymous variant with unknown significance was found in the MARVELD2 gene in several unrelated patients with MD. There is a burden of rare variation in certain SNHL genes in sporadic MD. Furthermore, the interaction of common and rare variants in SNHL genes may have an additive effect on MD phenotype. This study will contribute to design a gene panel for the genetic diagnosis of MD.