Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/15954
Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease
StatisticsItem usage statistics
MetadataShow Dublin Core item record
Document typeresearch article
CitationFrejo L, Gallego-Martinez A, Requena T, Martin-Sanz E, Amor-Dorado JC, Soto-Varela A, et al. Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease. Sci Rep. 2018 Apr 13;8:5974.
Epidemiological studies have found a higher prevalence of allergic symptoms and positive prick tests in patients with Meniere's disease (MD); however the effect of allergenic extracts in MD has not been established. Thus, this study aims to determine the effect of Aspergillus and Penicillium stimulation in cytokine release and gene expression profile in MD. Patients with MD showed higher basal levels of IL-1 beta, IL-1RA, IL-6 and TNF-alpha when compared to healthy controls. We observed that IL-1 beta levels had a bimodal distribution suggesting two different subgroups of patients, with low and high basal levels of cytokines. Gene expression profile in peripheral blood mononuclear cells (PBMC) showed significant differences in patients with high and low basal levels of IL-1 beta. We found that both mold extracts triggered a significant release of TNF-alpha in MD patients, which were not found in controls. Moreover, after mold stimulation, MD patients showed a different gene expression profile in PBMC, according to the basal levels of IL-1 beta. The results indicate that a subset of MD patients have higher basal levels of proinflammatory cytokines and the exposure to Aspergillus and Penicillium extracts may trigger additional TNF-alpha release and contribute to exacerbate inflammation.
Tumor Necrosis Factor-alpha
Enfermedad de Meniere
Factor de Necrosis Tumoral alfa
Persona de Mediana Edad
Estudios de Casos y Controles