Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/16029
Vitamin D deficiency in chronic inflammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study
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ISSN: 1478-6354
eISSN: 1478-6362
WOS ID: 000359526200001
Scopus EID: 2-s2.0-84940207503
PMID: 26271333
Embase PUI: L605581943
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2015-08-14Document type
research articleCitation
Urruticoechea-Arana A, Martin-Martinez MA, Castaneda S, Sanchez Piedra CA, Gonzalez-Juanatey C, Llorca J, et al. Vitamin D deficiency in chronic inflammatory rheumatic diseases: results of the cardiovascular in rheumatology [CARMA] study. Arthritis Res Ther. 2015 Aug 14;17:211.Abstract
Introduction: The aim was to study the association between 25-hydroxyvitamin D (25(OH) D) levels and the clinical characteristics of patients with chronic inflammatory rheumatic diseases (CIRD). Methods: We studied a cross-section from the baseline visit of the CARMA project (CARdiovascular in rheuMAtology), a 10-year prospective study evaluating the risk of cardiovascular events in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients, and non-CIRD patients who attended rheumatology outpatient clinics from 67 hospitals in Spain. Non-CIRD group was frequency matched by age with the joint distribution of the three CIRD groups included in the study. 25(OH) D deficiency was defined if 25(OH) D vitamin levels were < 20 ng/ml. Results: 2.234 patients (775 RA, 738 AS and 721 PsA) and 677 non-CIRD subjects were assessed. The median (p25-p75) 25(OH) D levels were: 20.4 (14.4-29.2) ng/ml in RA, 20.9 (13.1-29.0) in AS, 20.0 (14.0-28.8) in PsA, and 24.8 (18.4-32.6) ng/ml in non-CIRD patients. We detected 25(OH) D deficiency in 40.5 % RA, 39.7 % AS, 40.9 % PsA and 26.7 % non-CIRD controls (p < 0.001). A statistically significant positive association between RA and 25(OH) D deficiency was found (adjusted (adj.) OR = 1.46; 95 % CI = 1.09-1.96); p = 0.012. This positive association did not reach statistical significance for AS (adj. OR 1.23; 95 % CI = 0.85-1.80) and PsA (adj. OR 1.32; 95 % CI = 0.94-1.84). When the parameters of disease activity, severity or functional impairment were assessed, a marginally significant association between 25(OH) D deficiency and ACPA positivity in RA patients (adj. OR = 1.45; 95 % CI = 0.99-2.12; p = 0.056), and between 25(OH) D deficiency and BASFI in AS patients (adj. OR = 1.08; 95 % CI = 0.99-1.17); p = 0.07) was also found. Conclusions: Patients with RA show an increased risk of having 25(OH) D deficiency compared to non-CIRD controls.
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https://dx.doi.org/10.1186/s13075-015-0704-4MeSH
Cardiovascular DiseasesAged
Spain
Adult
Risk Assessment
Humans
Vitamin D Deficiency
Vitamin D
Middle Aged
Cross-Sectional Studies
Male
Multivariate Analysis
Prospective Studies
Arthritis, Rheumatoid
Female
Rheumatology
Risk Factors
Arthritis, Psoriatic
Spondylitis, Ankylosing
Chronic Disease
DeCS
Enfermedad CrónicaEspondilitis Anquilosante
Artritis Psoriásica
Femenino
Análisis Multivariante
Artritis Reumatoide
Masculino
Vitamina D
Deficiencia de Vitamina D
Estudios Transversales
Reumatología
Factores de Riesgo
Humanos
Persona de Mediana Edad
Estudios Prospectivos
Anciano
Medición de Riesgo
Enfermedades Cardiovasculares
Adulto
España