Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/16116
Delphi consensus on strategies in the management of opioid-induced constipation in cancer patients
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CitationGirones Sarrio R, Calsina-Berna A, Gozalvo Garcia A, Esparza-Minana JM, Falco Ferrer E, Porta-Sales J, et al. Delphi consensus on strategies in the management of opioid-induced constipation in cancer patients. BMC Palliat Care. 2021 Jan 02;20(1):1.
Background Opioid-induced constipation (OIC) is a frequent and bothersome adverse event related with opioid therapy in cancer patients. Despite the high prevalence, medical management of OIC is often uncertain. The current project aimed to investigate expert opinion on OIC management and provide practical recommendations to improve the clinical approach of OIC in cancer patient. Methods A modified Delphi method was conducted involving 46 different physicians experts in OIC. Using a structured questionnaire of 67 items this project intended to seek consensus on aspects related to diagnosis, treatment, and quality of life of cancer patients suffering with OIC. Results After two rounds, a consensus was reached in 91% of the items proposed, all in agreement. Agreement was obtained on OIC definition (95.7%). Objective and patient-reported outcomes included in that definition should be assessed routinely in clinical practice. Responsive to symptom changes and easy-to-use assessment tools were recommended (87.2%). Successful diagnosis of OIC requires increase clinicians awareness of OIC and proactivity to discuss symptoms with their patients (100%). Successful management of OIC requires individualization of the treatment (100%), regular revaluation once is established, and keeping it for the duration of opioid treatment (91.5%). Oral Peripherally Acting mu-Opioid Receptor Agonists (PAMORAs), were considered good alternatives for the treatment of OIC in cancer patients (97.9%). This drugs and laxatives can be co-prescribed if OIC coexist with functional constipation. Conclusions The panelists, based on their expert clinical practice, presented a set of recommendations for the management of OIC in cancer patients.
MeSHReceptors, Opioid, mu
Quality of Life
Patient Reported Outcome Measures
Estreñimiento Inducido por Opioides
Calidad de Vida
Medición de Resultados Informados por el Paciente
Dolor en Cáncer
Receptores Opioides mu