Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/16119
Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry
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ISSN: 0785-3890
eISSN: 1365-2060
WOS ID: 000584621700001
Scopus EID: 2-s2.0-85095665522
PMID: 33063540
Embase PUI: L2007160222
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Javier Carrasco-Sanchez, Francisco; Dolores Lopez-Carmona, Ma; Javier Martinez-Marcos, Francisco; Perez-Belmonte, Luis M.; Hidalgo-Jimenez, Alicia; Buonaiuto, Veronica; Suarez Fernandez, Carmen; Freire Castro, Santiago Jesus; Luordo, Davide; Pesqueira Fontan, Paula Maria; Blazquez Encinar, Julio Cesar; Magallanes Gamboa, Jeffrey Oskar; de la Pena Fernandez, Andres; Torres Pena, Jose David; Fernandez Sola, Joaquim; Napal Lecumberri, Jose Javier; Amoros Martinez, Francisco; Guisado Espartero, Maria Esther; Jorge Ripper, Carlos; Gomez Mendez, Raquel; Vicente Lopez, Natalia; Roman Bernal, Berta; Rojano Rivero, Maria Gloria; Ramos Rincon, Jose Manuel; Gomez Huelgas, Ricardo; SEMI-COVID-19 NetworkPublication date
2021-01-01Document type
research articleCitation
Carrasco-Sanchez FJ, Lopez-Carmona MD, Martinez-Marcos FJ, Perez-Belmonte LM, Hidalgo-Jimenez A, Buonaiuto V, et al. Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry. Ann Med. 2021 Jan 01;53(1):103-16.Abstract
Background Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. Methods This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140-180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality. Results Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140-180 mg) and 41.1% (>180 mg/dL), p.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. Conclusions Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. KEY MESSAGE Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.
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https://dx.doi.org/10.1080/07853890.2020.1836566Keywords
SARS-CoV-2COVID-19
hyperglycaemia
mortality
diabetes
MeSH
Coronavirus InfectionsAged, 80 and over
Aged
Blood Glucose
Spain
Length of Stay
Hyperglycemia
Critical Care
Humans
Middle Aged
Pandemics
Male
Female
Respiration, Artificial
COVID-19
Registries
Pneumonia, Viral
DeCS
FemeninoCOVID-19
Masculino
Tiempo de Internación
Humanos
Persona de Mediana Edad
Glucemia
Cuidados Críticos
Hiperglucemia
Anciano
Anciano de 80 o más Años
Neumonía Viral
Respiración Artificial
Infecciones por Coronavirus
España
Pandemias
Sistema de Registros