Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/16541
Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)
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AuthorObon-Santacana, Mireia; Romaguera, Dora ; Gracia-Lavedan, Esther; Molinuevo, Amaia; Molina-Montes, Esther; Shivappa, Nitin; Hebert, James R.; Tardon, Adonina; Castano-Vinyals, Gemma; Moratalla, Ferran; Guino, Elisabet; Marcos-Gragera, Rafael; Azpiri, Mikel; Gil, Leire; Olmedo-Requena, Rocio; Lozano-Lorca, Macarena; Alguacil, Juan; Fernandez-Villa, Tania; Martin, Vicente; Molina, Antonio J.; Ederra, Maria; Moreno-Iribas, Conchi; Perez, Beatriz; Aragones, Nuria; Castello, Adela; Huerta, Jose Ma; Dierssen-Sotos, Trinidad; Gomez-Acebo, Ines; Molina-Barcelo, Ana; Pollan, Marina; Kogevinas, Manolis; Moreno, Victor; Amiano, Pilar
Document typeresearch article
CitationObon-Santacana M, Romaguera D, Gracia-Lavedan E, Molinuevo A, Molina-Montes E, Shivappa N, et al. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients. 2019 Jun;11(6):1406.
Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII (R)), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99-1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.
dietary inflammatory index
Factores de Riesgo
Medición de Riesgo
Neoplasias de la Mama
Estudios de Casos y Controles