Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/16605
Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
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eISSN: 1471-244X
WOS ID: 000311801200001
Scopus EID: 2-s2.0-84866303942
PMID: 22988986
Embase PUI: L52220287
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2012-09-18Document type
research articleCitation
Garcia-Toro M, Medina E, Galan JL, Gonzalez MA, Maurino J. Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment. BMC Psychiatry. 2012 Sep 18;12:143.Abstract
Background: The aim of the study was to determine the most common pharmacological strategies used in the management of major depressive disorder (MDD) after an inadequate response to first-line antidepressant treatment in clinical practice. Methods: Multicenter, non-interventional study in adult outpatients with a DSM-IV-TR diagnosis of MDD and inadequate response to first-line antidepressant medication. Multiple logistic regression analyses were performed to identify independent factors associated with the adoption of a specific second-line strategy. Results: A total of 273 patients were analyzed (mean age: 46.8 years, 67.8% female). Baseline mean Montgomery-Asberg Depression Rating Scale total score was 32.1 (95% CI 31.2-32.9). The most common strategies were: switching antidepressant medication (39.6%), augmentation (18.8%), and combination therapy (17.9%). Atypical antipsychotic drugs were the most commonly used agent for augmenting antidepressant effect. The presence of psychotic symptoms and the number of previous major depressive episodes were associated with the adoption of augmenting strategy (OR = 3.2 and 1.2, respectively). Conclusion: The switch to another antidepressant agent was the most common second-line therapeutic approach. Psychiatrists chose augmentation based on a worse patients' clinical profile (number of previous episodes and presence of psychotic symptoms).
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https://dx.doi.org/10.1186/1471-244X-12-143Keywords
Major depressive disorderResponse
Antidepressant treatment
Augmentation
Switching
Combination
MeSH
MaleDepressive Disorder, Major
Psychiatric Status Rating Scales
Adult
Female
Antidepressive Agents
Drug Synergism
Treatment Outcome
Humans
Drug Therapy, Combination
Middle Aged
Disease Management
DeCS
Manejo de la EnfermedadResultado del Tratamiento
Antidepresivos
Quimioterapia Combinada
Escalas de Valoración Psiquiátrica
Trastorno Depresivo Mayor
Humanos
Persona de Mediana Edad
Sinergismo Farmacológico
Femenino
Adulto
Masculino