Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/16625
Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection
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AuthorPaquette, Stephane G.; Banner, David; Zhao, Zhen; Fang, Yuan; Huang, Stephen S. H.; Leon, Alberto J.; Ng, Derek C. K.; Almansa, Raquel; Martin-Loeches, Ignacio; Ramirez, Paula; Socias Crespi, Lorenzo ; Loza, Ana; Blanco, Jesus; Sansonetti, Paola; Rello, Jordi; Andaluz, David; Shum, Bianche; Rubino, Salvatore; Ortiz de Lejarazu, Raul; Tran, Dat; Delogu, Giovanni; Fadda, Giovanni; Krajden, Sigmund; Rubin, Barry B.; Bermejo-Martin, Jesus F.; Kelvin, Alyson A.; Kelvin, David J.
Document typeresearch article
CitationPaquette SG, Banner D, Zhao Z, Fang Y, Huang SSH, Leon AJ, et al. Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection. PLoS One. 2012 Jun 05;7(6):e38214. Epub 2012 Jun 5.
Pandemic H1N1 influenza A (H1N1pdm) is currently a dominant circulating influenza strain worldwide. Severe cases of H1N1pdm infection are characterized by prolonged activation of the immune response, yet the specific role of inflammatory mediators in disease is poorly understood. The inflammatory cytokine IL-6 has been implicated in both seasonal and severe pandemic H1N1 influenza A (H1N1pdm) infection. Here, we investigated the role of IL-6 in severe H1N1pdm infection. We found IL-6 to be an important feature of the host response in both humans and mice infected with H1N1pdm. Elevated levels of IL-6 were associated with severe disease in patients hospitalized with H1N1pdm infection. Notably, serum IL-6 levels associated strongly with the requirement of critical care admission and were predictive of fatal outcome. In C57BL/6J, BALB/cJ, and B6129SF2/J mice, infection with A/Mexico/4108/2009 (H1N1pdm) consistently triggered severe disease and increased IL-6 levels in both lung and serum. Furthermore, in our lethal C57BL/6J mouse model of H1N1pdm infection, global gene expression analysis indicated a pronounced IL-6 associated inflammatory response. Subsequently, we examined disease and outcome in IL-6 deficient mice infected with H1N1pdm. No significant differences in survival, weight loss, viral load, or pathology were observed between IL-6 deficient and wild-type mice following infection. Taken together, our findings suggest IL-6 may be a potential disease severity biomarker, but may not be a suitable therapeutic target in cases of severe H1N1pdm infection due to our mouse data.
Mice, Inbred BALB C
Mice, Inbred C57BL
Influenza A Virus, H1N1 Subtype
Subtipo H1N1 del Virus de la Influenza A
Ratones Endogámicos C57BL
Infecciones por Orthomyxoviridae
Ratones Endogámicos BALB C