Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/16801
Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (or CCL2) in the Regulation of Metabolism
StatisticsItem usage statistics
MetadataShow Dublin Core item record
Document typeresearch article
CitationRull A, Camps J, Alonso-Villaverde C, Joven J. Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (or CCL2) in the Regulation of Metabolism. Mediat Inflamm. 2010;2010:326580. Epub 2010 Sep 23.
To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate nutrient-sensing pathways with the immune response. This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory and metabolic pathways are convergent at multiple levels. Recruitment of macrophages to metabolically compromised tissue is a primary event in which chemokines play a crucial role. However, chemokines may also transmit cell signals that generate multiple responses, most unrelated to chemotaxis, that are involved in different biological processes. We have reviewed the evidence showing that monocyte chemoattractant protein-1 (MCP-1 or CCL2) may have a systemic role in the regulation of metabolism that sometimes is not necessarily linked to the traffic of inflammatory cells to susceptible tissues. Main topics cover the relationship betweenMCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.
Resistencia a la Insulina