Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/17013
Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis
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ISSN: 0342-4642
eISSN: 1432-1238
WOS ID: 000262549100007
Scopus EID: 2-s2.0-58549105895
PMID: 18972101
Embase PUI: L50316847
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2009-01Document type
review articleCitation
Guery Benoit P, Arendrup Maiken C, Auzinger G, Azoulay E, Borges Sa M, Johnson EM, et al. Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis. Intensive Care Med. 2009 Jan;35(1):55-62. Epub 2008 Oct 30.Abstract
Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting, particularly in the intensive care unit (ICU). To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and a European expert panel discussion. Candida albicans remains the most frequently isolated fungal species followed by C. glabrata. The diagnosis of invasive candidiasis involves both clinical and laboratory parameters, but neither of these are specific. One of the main features in diagnosis is the evaluation of risk factor for infection which will identify patients in need of pre-emptive or empiric treatment. Clinical scores were built from those risk factors. Among laboratory diagnosis, a positive blood culture from a normally sterile site provides positive evidence. Surrogate markers have also been proposed like 1,3 beta-d glucan level, mannans, or PCR testing. Invasive candidiasis and candidemia is a growing concern in the ICU, apart from cases with positive blood cultures or fluid/tissue biopsy, diagnosis is neither sensitive nor specific. The diagnosis remains difficult and is usually based on the evaluation of risk factors.
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https://dx.doi.org/10.1007/s00134-008-1338-7Keywords
AntifungalAzole
Candida
Candidiasis
Echinocandins
Invasive candidiasis
Intensive care
Polyenes
MeSH
Intensive Care UnitsBiomarkers
Europe
Cross Infection
Humans
Fungemia
Prevalence
Candidiasis
Turkey
DeCS
CandidiasisTurquia
Fungemia
Humanos
Prevalencia
Biomarcadores
Infección Hospitalaria
Europa (Continente)
Unidades de Cuidados Intensivos