Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/17109
Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study
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AuthorPapandreou, Christopher; Hernandez-Alonso, Pablo; Bullo, Monica; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferre, Marta; Toledo, Estefanía; Dennis, Courtney; Deik, Amy A.; Clish, Clary; Razquin, Cristina; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Aros, Fernando; Fiol Sala, Miquel ; Lapetra, Jose; Ruano, Cristina; Liang, Liming; Martinez-Gonzalez, Miguel A.; Hu, Frank B.; Salas-Salvado, Jordi
Document typeresearch article
CitationPapandreou C, Hernandez-Alonso P, Bullo M, Ruiz-Canela M, Yu E, Guasch-Ferre M, et al. Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study. Nutrients. 2019 May;11(5):1032.
Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate between coffee consumption categories. This is a cross-sectional analysis of 1664 participants from the PREDIMED study. Metabolites were semiquantitatively profiled using a multiplatform approach. Consumption of total coffee, caffeinated coffee and decaffeinated coffee was assessed by using a validated food frequency questionnaire. We assessed associations between 387 metabolite levels with total, caffeinated, or decaffeinated coffee consumption (50 mL coffee/day) using elastic net regression analysis. Ten-fold cross-validation analyses were used to estimate the discriminative accuracy of metabolites for total and subtypes of coffee. We identified different sets of metabolites associated with total coffee, caffeinated and decaffeinated coffee consumption. These metabolites consisted of lipid species (e.g., sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine) or were derived from glycolysis (alpha-glycerophosphate) and polyphenol metabolism (hippurate). Other metabolites included caffeine, 5-acetylamino-6-amino-3-methyluracil, cotinine, kynurenic acid, glycocholate, lactate, and allantoin. The area under the curve (AUC) was 0.60 (95% CI 0.56-0.64), 0.78 (95% CI 0.75-0.81) and 0.52 (95% CI 0.49-0.55), in the multimetabolite model, for total, caffeinated, and decaffeinated coffee consumption, respectively. Our comprehensive metabolic analysis did not result in a new, reliable potential set of metabolites for coffee consumption.
Estudios de Cohortes
Persona de Mediana Edad
Estudios de Casos y Controles
This item appears in following Docusalut collectionsHospital Universitario Son Espases - HUSE > Comunicación científica
Instituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica