Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/17153
The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms
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AuthorBenito, Natividad; Mur, Isabel; Ribera, Alba; Soriano, Alex; Rodriguez-Pardo, Dolors; Sorli, Luisa; Cobo, Javier; Fernandez-Sampedro, Marta; del Toro, Maria Dolores; Guio, Laura; Praena, Julia; Bahamonde, Alberto; Riera, Melchor ; Esteban, Jaime; Mirena Baraia-Etxaburu, Josu; Martinez-Alvarez, Jesus; Jover-Saenz, Alfredo; Duenas, Carlos; Ramos, Antonio; Sobrino, Beatriz; Euba, Gorane; Morata, Laura; Pigrau, Carles; Horcajada, Juan P.; Coll, Pere; Crusi, Xavier; Ariza, Javier; Garcia-Gonzalez, Merce; Perez-Villar, Ferran; Prats-Gispert, Laura; Ramirez-Hidalgo, Maria; De-la-Pena-Trigueros, Mireia; Lopez-Azkarreta, Inigo; Lopez-Martinez, Miriam; Lora-Tamayo, Jaime; Murillo, Oscar; Pedrero, Salvador; Amador, Juan; Garcia-Paino, Luis; Parrondo, Susana; Raya, Carmen; Moreno, Alfonso; Aranzazu Blanco-Martinez-de-Morentin, Maria; Genoveva Zapico-Aldea, Laura Rodriguez-Fernandez; Lozano, Luis; Munoz-Mahamud, Ernesto; Merino-Perez, Josu; Alier, Albert; Prim, Nuria; Puig, Luis; Aunon, Alvaro; Blanco, Antonio; Garcia-Canete, Joaquin; Parron-Cambero, Raul; Carmen Farinas, M.; Manuel-Bloque, Ricardo; Salas-Venero, Carlos; Campo-Loarte, Jesus; Munez-Rubio, Elena; Sanchez-Romero, Isabel; Escudero-Sanchez, Rosa; Ruiz-Carbajosa, Patricia; Gonzalez, Aranzazu; Carlos Gonzalez, Jose; Jordan, Marcos; Rivera, Alba; Marinescu, Carmen; Montaner, Francisco; Ramirez, Antonio; Corona, Pablo S.; Lung, Maily; Puig-Asensio, Mireia; Angel Muniain-Ezcurra, Miguel; Penas-Espinar, Cecilia; Isabel Suarez, Ana; Jose Gomez, Maria; Lopez-Pliego, Macarena; REIPI Spanish Network Res Infect D; SEIMC Spanish Soc Infect Dis Clini
Document typeresearch article
CitationBenito N, Mur I, Ribera A, Soriano A, Rodriguez-Pardo D, Sorli L, et al. The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. J Clin Med. 2019 May;8(5):673.
The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)including multidrug-resistant organisms (MDRO)by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and positive intraoperative cultures (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2-3 months, 4-12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
Keywordsprosthetic joint infections
classification schemes for prosthetic joint infections
antimicrobial empirical treatment
This item appears in following Docusalut collectionsHospital Universitario Son Espases - HUSE > Comunicación científica
Instituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica