Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/17264
Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial
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DOI: 10.2337/dc18-0836
ISSN: 0149-5992
eISSN: 1935-5548
WOS ID: 000465238900018
Scopus EID: 2-s2.0-85062162906
PMID: 30389673
Embase PUI: L2001979560
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Salas-Salvado, Jordi; Diaz-Lopez, Andres; Ruiz-Canela, Miguel; Basora, Josep; Fito, Montserrat; Corella, Dolores; Serra-Majem, Luis; Waernberg, Julia; Romaguera, Dora





Publication date
2019-05Document type
research articleCitation
Salas-Salvado Jordi, Diaz-Lopez Andres, Ruiz-Canela Miguel, Basora Josep, Fito Montse, Corella Dolores, et al. Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial. Diabetes Care. 2019 May;42(5):777-788. Epub 2018 Nov 2.Abstract
OBJECTIVE The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvencion con DIeta MEDiterranea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention. RESEARCH DESIGN AND METHODS Overweight/obese adults with metabolic syndrome aged 55-75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively. RESULTS Diet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P < 0.001), a mean difference of -2.5 kg (95% CI -3.1 to -1.9). Weight loss >= 5% occurred in 33.7% of IG participants compared with 11.9% in the CG (P < 0.001). Compared with the CG, cardiovascular risk factors, including waist circumference, fasting glucose, triglycerides, and HDL cholesterol, significantly improved in IG participants (P < 0.002). Reductions in insulin resistance, HbA(1c), and circulating levels of leptin, interleukin-18, and MCP-1 were greater in IG than CG participants (P < 0.05). IG participants with prediabetes/diabetes significantly improved glycemic control and insulin sensitivity, along with triglycerides and HDL cholesterol levels compared with their CG counterparts. CONCLUSIONS PREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes.
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https://dx.doi.org/10.2337/dc18-0836MeSH
Cardiovascular DiseasesMetabolic Syndrome
Aged
Blood Glucose
Follow-Up Studies
Humans
Life Style
Behavior Therapy
Middle Aged
Obesity
Prediabetic State
Male
Exercise Therapy
Female
Risk Factors
Diet, Mediterranean
Weight Loss
Caloric Restriction
Overweight
Exercise
DeCS
Pérdida de PesoDieta Mediterránea
Ejercicio Físico
Terapia por Ejercicio
Síndrome Metabólico
Femenino
Masculino
Restricción Calórica
Estudios de Seguimiento
Factores de Riesgo
Humanos
Persona de Mediana Edad
Obesidad
Glucemia
Terapia Conductista
Estilo de Vida
Estado Prediabético
Anciano
Enfermedades Cardiovasculares
Sobrepeso
This item appears in following Docusalut collections
Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica