Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/17294
Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review
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ISSN: 1007-9327
eISSN: 2219-2840
WOS ID: 000407559600006
Scopus EID: 2-s2.0-85026530097
PMID: 28811706
Embase PUI: L617613496
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2017-07-28Document type
review articleCitation
Salaritabar A, Darvishi B, Hadjiakhoondi F, Manayi A, Sureda Gomila A, Nabavi Seyed F, et al. Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review. World J Gastroenterol. 2017 Jul 28;23(28):5097-114.Abstract
The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune and neurodegenerative diseases, metabolic syndrome, and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease (CD) and ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody diarrhea, pain, fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However, surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants, including vegetables and fruits which are the major dietary sources of these compounds for humans, together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids, evidencing a remarkable free-radical scavenging capacity. However, accumulating evidence suggests that flavonoids have many other biological properties, including anti-inflammatory, antiviral, anticancer, and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs.
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https://dx.doi.org/10.3748/wjg.v23.i28.5097MeSH
Disease Models, AnimalColon
Clinical Trials as Topic
Flavonoids
Colitis, Ulcerative
Animals
Treatment Outcome
Crohn Disease
Anti-Inflammatory Agents
Intestinal Mucosa
DeCS
AnimalesResultado del Tratamiento
Antiinflamatorios
Enfermedad de Crohn
Colon
Mucosa Intestinal
Colitis Ulcerosa
Ensayos Clínicos como Asunto
Flavonoides
Modelos Animales de Enfermedad