Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/17508
Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study
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DOI: 10.1038/bjc.2013.270
ISSN: 0007-0920
WOS ID: 000321003700020
Scopus EID: 2-s2.0-84879685770
PMID: 23722472
Embase PUI: L52607944
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de la Piedra, Concepcion; Alcaraz, A.; Bellmunt, J.; Meseguer, C.; Gomez-Caamano, A.; Ribal, M. J.; Vazquez, F.; Anido, Urbano; Samper, P.; Esteban, E.; Alvarez-Ossorio, J. L.; Lara, P. C.; San Jose, L. A.; Contreras, J. A.; Gonzalez Del Alba, Aranzazu; González Gragera, Belén

Publication date
2013-06-25Document type
research articleCitation
De La Piedra C, Alcaraz A, Bellmunt J, Meseguer C, Gomez-Caamano A, Ribal M J, et al. Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study. Br J Cancer. 2013 Jun 25;108(12):2565-72. Epub 2013 May 30.Abstract
Background: Owing to the limited validity of clinical data on the treatment of prostate cancer (PCa) and bone metastases, biochemical markers are a promising tool for predicting survival, disease progression and skeletal-related events (SREs) in these patients. The aim of this study was to evaluate the predictive capacity of biochemical markers of bone turnover for mortality risk, disease progression and SREs in patients with PCa and bone metastases undergoing treatment with zoledronic acid (ZA). Methods: This was an observational, prospective and multicenter study in which ninety-eight patients were included. Patients were treated with ZA (4mg every 4 weeks for 18 months). Data were collected at baseline and 3, 6, 9, 12, 15 and 18 months after the beginning of treatment. Serum levels of bone alkaline phosphtase (BALP), aminoterminal propeptide of procollagen type I (P1NP) and beta-isomer of carboxiterminal telopeptide of collagen I (beta-CTX) were analysed at all points in the study. Data on disease progression, SREs development and survival were recorded. Results: Cox regression models with clinical data and bone markers showed that the levels of the three markers studied were predictive of survival time, with beta-CTX being especially powerful, in which a lack of normalisation in visit 1 (3 months after the beginning of treatment) showed a 6.3-times more risk for death than in normalised patients. Levels of these markers were also predictive for SREs, although in this case BALP and P1NP proved to be better predictors. We did not find any relationship between bone markers and disease progression. Conclusion: In patients with PCa and bone metastases treated with ZA, beta-CTX and P1NP can be considered suitable predictors for mortality risk, while BALP and P1NP are appropriate for SREs. The levels of these biomarkers 3 months after the beginning of treatment are especially important.
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https://dx.doi.org/10.1038/bjc.2013.270Keywords
prostate cancerbone metastases
bone markers
overall survival
disease progression
skeletal-related events
MeSH
Aged, 80 and overDisease Progression
Aged
Bone Neoplasms
Follow-Up Studies
Humans
Middle Aged
Prognosis
Bone Density Conservation Agents
Diphosphonates
Male
Biomarkers
Predictive Value of Tests
Risk Factors
Imidazoles
Bone Remodeling
Prostatic Neoplasms
Survival Analysis
DeCS
ImidazolesBiomarcadores
Remodelación Ósea
Análisis de Supervivencia
Difosfonatos
Masculino
Estudios de Seguimiento
Factores de Riesgo
Conservadores de la Densidad Ósea
Humanos
Persona de Mediana Edad
Valor Predictivo de las Pruebas
Pronóstico
Anciano
Anciano de 80 o más Años
Progresión de la Enfermedad
Neoplasias de la Próstata
Neoplasias Óseas
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Hospital Universitario Son Espases - HUSE > Comunicación científicaHospital Universitario Son Llàtzer - HUSLL > Comunicación científica