Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/18100
Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
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AuthorBiezma, María Isabel; Muñoz, Patricia; De la Villa, Sofía; Fariñas-Álvarez, Mª Carmen; Arnáiz de Las Revillas, Francisco; Gutierrez-Carretero, Encarnación; De Alarcón, Arístides; Rodríguez-García, Raquel; Llopis, Jaume; Goenaga, Miguel Ángel; Gutierrez-Villanueva, Andrea; Plata, Antonio; Vidal Bonet, Laura; Martínez-Sellés, Manuel; On Behalf Of Games, null
Document typeresearch article
CitationBiezma M, Muñoz P, De la Villa S, Fariñas-Álvarez M, Arnáiz de las Revillas F, Gutierrez-Carretero E, et al. Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences. J Clin Med. 2022 May 9;11(9):2651.
Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Retrospective analysis of the Spanish IE Registry (2008-2020). The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16-1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21-1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06-1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26-2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.