Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort

Martínez-Urbistondo, Diego; San Cristóbal, RodrigoSan; Villares, Paula; Martínez-González, Miguel Ángel; Babio, Nancy; Corella, Dolores; Del Val, José Luis; Ordovás, José M; Alonso-Gómez, Ángel M; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López-Miranda, José; Estruch, Ramon; Tinahones, Francisco J; Lapetra, José; Serra-Majem, J Luís; Bueno-Cavanillas, Aurora; Tur, Josep Antoni; Marcos, Alba; Pintó, Xavier; Delgado-Rodríguez, Miguel; Matía-Martín, Pilar; Vidal, Josep; Vázquez, Clotilde; Ros, Emilio; Bullón Vela, María Vanessa; Palau, Antoni; Masagué, Marta; Abete, Itziar; Moreno-Rodríguez, Anai; Candela-García, Inma; Konieczna, Jadwiga; García-Ríos, Antonio; Juárez, Oscar Lecea; Martín, Paco; Goday, Albert; Zulet, M Ángeles; Vaquero-Luna, Jessica; Orea, María Del Carmen Sayón; Megías, Isabel; Baltasar, Enric; Martínez, J Alfredo; Daimiel, Lidia

doi:10.3389/fendo.2022.868795

Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/18128

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Identifiers

URI: http://hdl.handle.net/20.500.13003/18128

DOI: 10.3389/fendo.2022.868795

ISSN: 1664-2392

WOS ID: 000835976900001

Scopus EID: 2-s2.0-85134176497

PMID: 35846291

Embase PUI: L2018233028

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Publication date

2022

Document type

research article

Citation

Martínez-Urbistondo D, San Cristóbal R, Villares P, Martínez-González MÁ, Babio N, Corella D, et al. Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort. Front Endocrinol (Lausanne). 2022 Jun 29;13.

Abstract

To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (β 0.64 vs β 0.05 per er-MeDiet adherence point, p< 0.01) and PA (β 0.05 vs β 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870).