Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/18461
Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?
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eISSN: 1422-0067
WOS ID: 000882297400001
Scopus EID: 2-s2.0-85141587756
PMID: 36361914
Embase PUI: L2020040760
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2022-10-28Document type
research articleCitation
Chaplin A, Rodriguez RM, Segura-Sampedro JJ, Ochogavía-Seguí A, Romaguera D, Barceló-Coblijn G. Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link? Int J Mol Sci. 2022 Oct 28;23(21):13128.Abstract
Colorectal cancer (CRC) is a major health problem worldwide, with an estimated 1.9 million new cases and 915,880 deaths in 2020 alone. The etiology of CRC is complex and involves both genetic and lifestyle factors. Obesity is a major risk factor for CRC, and the mechanisms underlying this link are still unclear. However, the generalized inflammatory state of adipose tissue in obesity is thought to play a role in the association between CRC risk and development. Visceral adipose tissue (VAT) is a major source of proinflammatory cytokines and other factors that contribute to the characteristic systemic low-grade inflammation associated with obesity. VAT is also closely associated with the tumor microenvironment (TME), and recent evidence suggests that adipocytes within the TME undergo phenotypic changes that contribute to tumor progression. In this review, we aim to summarize the current evidence linking obesity and CRC, with a focus on the role of VAT in tumor etiology and progression.
Publisher version
https://doi.org/10.3390/ijms232113128MeSH
Tumor MicroenvironmentIntra-Abdominal Fat
Colorectal Neoplasms
Humans
Adipocytes
Adipose Tissue
Inflammation
Obesity
DeCS
Grasa IntraabdominalTejido Adiposo
Neoplasias Colorrectales
Humanos
Obesidad
Adipocitos
Inflamación
Microambiente Tumoral
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Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica