Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/9064
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study
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ISSN: 2045-2322
WOS ID: 000448814600026
Scopus EID: 2-s2.0-85055818232
PMID: 30382190
Embase PUI: L624724993
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Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Toledo, Estefania; Corella, Dolores; Salas-Salvado, Jordi; Cuenca-Royo, Aida; Vioque, Jesus; Romaguera, Dora





Publication date
2018-10-31Document type
research articleCitation
Mallorqui-Bague N, Lozano-Madrid M, Toledo E, Corella D, Salas-Salvado J, Cuenca-Royo A, et al. Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. Sci Rep. 2018 Oct 31;8:16128.Abstract
This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c >= 53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
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https://dx.doi.org/10.1038/s41598-018-33843-8MeSH
Diabetes Mellitus, Type 2Metabolic Syndrome
Aged
Male
Female
Body Mass Index
Humans
Cognitive Dysfunction
Middle Aged
Cross-Sectional Studies
Glycated Hemoglobin A
Obesity
DeCS
Índice de Masa CorporalDisfunción Cognitiva
Estudios Transversales
Humanos
Persona de Mediana Edad
Obesidad
Síndrome Metabólico
Anciano
Diabetes Mellitus Tipo 2
Femenino
Hemoglobina A Glucada
Masculino
This item appears in following Docusalut collections
Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica