Identifier to cite or link to this item: http://hdl.handle.net/20.500.13003/9146
Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
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ISSN: 0903-1936
eISSN: 1399-3003
WOS ID: 000452391500012
Scopus EID: 2-s2.0-85054464320
PMID: 30209194
Embase PUI: L2002034412
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Contreras, Zuelma A.; Chen, Zhanghua; Roumeliotaki, Theano; Annesi-Maesano, Isabella; Baiz, Nour; von Berg, Andrea; Bergstrom, Anna; Crozier, Sarah; Duijts, Liesbeth; Ekström, Sandra; Eller, Esben E.; Fantini, Maria Pia; Kjaer, Henrik Fomsgaard; Forastiere, Francesco; Gerhard, Beatrix; Gori, Davide; Harskamp-van Ginkel, Margreet W.; Heinrich, Joachim; Iniguez, Carmen; Inskip, Hazel; Keil, Thomas; Kogevinas, Manolis; Lau, Susanne; Lehmann, Irina; Maier, Dieter; van Meel, Evelien R.; Mommers, Monique; Murcia, Mario; Porta, Daniela; Smit, Henriette A.; Standl, Marie; Stratakis, Nikos; Sunyer, Jordi; Thijs, Carel; Torrent Quetglas, Maties

Publication date
2018-09-01Document type
research articleCitation
Contreras Zuelma A., Chen Zhanghua, Roumeliotaki Theano, Annesi-Maesano Isabella, Baiz Nour, Von Berg Andrea, et al. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. Eur Resp J. 2018 Sep 01;52(3):1800504.Abstract
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood. This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age. Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09). Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
Publisher version
https://dx.doi.org/10.1183/13993003.00504-2018MeSH
ChildAsthma
Humans
Child, Preschool
Rhinitis, Allergic
Pediatric Obesity
Phenotype
Male
Europe
Female
Risk Factors
Age of Onset
Cohort Studies
Respiratory Sounds
DeCS
Estudios de CohortesEdad de Inicio
Femenino
Europa (Continente)
Obesidad Pediátrica
Masculino
Rinitis Alérgica
Factores de Riesgo
Preescolar
Humanos
Asma
Fenotipo
Niño
Ruidos Respiratorios
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Instituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científicaÁrea de Salud de Menorca - ASME > Comunicación científica