RT Journal Article
T1 Statin therapy and outcome in Takotsubo syndrome patients: Results from the multicenter international GEIST registry
A1 Novo, Giuseppina
A1 Arcari, Luca
A1 Stiermaier, Thomas
A1 Alaimo, Chiara
A1 El-Battrawy, Ibrahim
A1 Cacciotti, Luca
A1 Guerra, Federico
A1 Musumeci, Beatrice
A1 Mariano, Enrica
A1 Parisi, Giuseppe
A1 Montisci, Roberta
A1 Vazirani, Ravi
A1 Pérez-Castellanos, Alberto
A1 Uribarri, Aitor
A1 Corbí-Pascual, Miguel
A1 Salamanca, Jorge
A1 Akin, Ibrahim
A1 Thiele, Holger
A1 Brunetti, Natale Daniele
A1 Eitel, Ingo
A1 Núñez Gil, Iván J
A1 Santoro, Francesco
AB Several studies have shown that endothelial dysfunction plays a role in the pathogenesis of Takotsubo syndrome (TTS). Given the potential benefit of statin therapy on endothelial dysfunction, we hypothesized that such treatment could improve outcome. Aim of our study was to evaluate clinical characteristics and outcome of TTS patients treated with statin therapy.Patients were enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry. Demographic data, clinical features and drug therapy at discharge were recorded. Primary study outcome was the occurrence of all-cause death at follow-up.Study population included 2429 consecutive TTS patients: 1293 (53.2%) discharged on statin and 1136 (46.8%) without statin. Patients with statin were older (age 72 ± 11 vs 69 ± 13 years, p < 0.001), with higher prevalence of hypertension (74.3% vs 60.3%, p < 0.001), diabetes (21.1% vs 14.7%, p < 0.001), dyslipidemia (56.1% vs 23.3%, p < 0.001), history of coronary artery disease (13.3% vs 6.3%, p < 0.001) and lower rates of in-hospital complications (14.7% vs 19.3%, p = 0.003). Survival analysis showed similar mortality rates between groups (log rank p = 0.803). At univariable analysis, statin therapy at discharge was not associated with lower mortality (HR: 0.97, 95% CI 0.74-1.26, p = 0.803). At multivariable analysis age (HR: 1.06 95% CI 1.04-1.08, p < 0.001), male sex (HR: 1.83, 95% CI 1.20-2.80, p = 0.005), diabetes (HR: 2.55, 95% CI 1.83-3.54 p < 0.001), malignancies (HR: 2.41, 95% CI 1.68-3.44, p < 0.001) and physical trigger (HR: 2.24, 95% CI 1.62-3.10, p < 0.001) were associated with increased mortality.Statin therapy after a TTS event was not associated with better prognosis at follow-up.
PB Elsevier
YR 2024
FD 2024-02
LK https://hdl.handle.net/20.500.13003/20240
UL https://hdl.handle.net/20.500.13003/20240
LA eng
NO Novo G, Arcari L, Stiermaier T, Alaimo C, El-Battrawy I, Cacciotti L, et al. Statin therapy and outcome in Takotsubo syndrome patients: Results from the multicenter international GEIST registry. Atherosclerosis. 2024 Feb;389:117421.
DS Docusalut
RD 12 jul. 2026