RT Journal Article T1 The Role of Physical Exercise as a Therapeutic Tool to Improve Lipedema: A Consensus Statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF) A1 Annunziata, Giuseppe A1 Paoli, Antonio A1 Manzi, Vincenzo A1 Camajani, Elisabetta A1 Laterza, Francesco A1 Verde, Ludovica A1 Capó Fiol, Xavier A1 Padua, Elvira A1 Bianco, Antonino A1 Carraro, Attilio A1 Di Baldassarre, Angela A1 Guidetti, Laura A1 Marcora, Samuele Maria A1 Orrù, Stefania A1 Tessitore, Antonio A1 Di Mitri, Roberto A1 Auletta, Lucia A1 Piantadosi, Angela A1 Bellisi, Mario A1 Palmeri, Edmondo A1 Savastano, Silvia A1 Colao, Annamaria A1 Caprio, Massimiliano A1 Muscogiuri, Giovanna A1 Barrea, Luigi AB This consensus statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF) provides the official view on the role of exercise as a non-pharmacological approach in lipedema. In detail, this consensus statement SISMeS - SIF aims to provide a comprehensive overview of lipedema, focusing, in particular, on the role played by physical exercise (PE) in the management of its clinical features.Lipedema is a chronic disease characterized by abnormal fat accumulation. It is often misdiagnosed as obesity, despite presenting distinct pathological mechanisms. Indeed, recent evidence has reported differences in adipose tissue histology, metabolomic profiles, and gene polymorphisms associated with this condition, adding new pieces to the complex puzzle of lipedema pathophysiology. Although by definition lipedema is a condition resistant to diet and PE, the latter emerges for its key role in the management of lipedema, contributing to multiple benefits, including improvements in mitochondrial function, lymphatic drainage, and reduction of inflammation. Various types of exercise, such as aquatic exercises and strength training, have been shown to alleviate symptoms and improve the quality of life of patients with lipedema. However, standardized guidelines for PE prescription and long-term management of patients with lipedema are lacking, highlighting the need for recommendations and further research in this area in order to optimise therapeutic strategies. PB Springer YR 2024 FD 2024-07-03 LK https://hdl.handle.net/20.500.13003/20640 UL https://hdl.handle.net/20.500.13003/20640 LA eng NO Annunziata G, Paoli A, Manzi V, Camajani E, Laterza F, Verde L, et al. The Role of Physical Exercise as a Therapeutic Tool to Improve Lipedema: A Consensus Statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società It. Curr Obes Rep. 2024 Jul 3. DS Docusalut RD 21 jul. 2026